Cargando…

Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFβ/SMAD3 and JAK2/STAT3 Signaling Pathways

Natural flavonoid pectolinarigenin (PEC) was reported to alleviate tubulointerstitial fibrosis of unilateral ureteral obstruction (UUO) mice in our previous study. To further investigate nephroprotective effects of PEC in hyperuricemic nephropathy (HN), adenine and potassium oxonate induced HN mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Qian, Wang, Bo, Guo, Fan, Huang, Rongshuang, Tan, Zhouke, Ma, Liang, Fu, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829971/ https://www.ncbi.nlm.nih.gov/pubmed/35153751 http://dx.doi.org/10.3389/fphar.2021.792139

Ejemplares similares

Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis
por: Li, Yali, et al.
Publicado: (2019)

Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways
por: Yang, Linli, et al.
Publicado: (2020)

Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats
por: Xiong, Chongxiang, et al.
Publicado: (2021)

Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy
por: Shi, Yingfeng, et al.
Publicado: (2020)

Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway
por: Hu, Xue, et al.
Publicado: (2021)

CXCL6 Promotes Renal Interstitial Fibrosis in Diabetic Nephropathy by Activating JAK/STAT3 Signaling Pathway
por: Sun, Meng-Yao, et al.
Publicado: (2019)

Isolation and Biological Properties of the Natural Flavonoids Pectolinarin and Pectolinarigenin—A Review
por: Cheriet, Thamere, et al.
Publicado: (2020)

Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice
por: Xu, Lieqiang, et al.
Publicado: (2021)

SKLB023 hinders renal interstitial fibrosis in obstructive nephropathy by interfering TGF-β1/Smad3 signaling
por: Feng, Yanhuan, et al.
Publicado: (2018)

Astragaloside IV improves the pharmacokinetics of febuxostat in rats with hyperuricemic nephropathy by regulating urea metabolism in gut microbiota
por: Zhao, Zhen Xiong, et al.
Publicado: (2022)

ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway
por: Shen, Yu-Li, et al.
Publicado: (2020)

Shuxie-1 Decoction Alleviated CUMS -Induced Liver Injury via IL-6/JAK2/STAT3 Signaling
por: Zhang, Mengting, et al.
Publicado: (2022)

Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion
por: Li, Xuechen, et al.
Publicado: (2020)

ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β-Smad2/3 Signaling-Mediated Lung Fibroblast Activation
por: Chen, Dongxin, et al.
Publicado: (2022)

Scutellarin Ameliorates Renal Injury via Increasing CCN1 Expression and Suppressing NLRP3 Inflammasome Activation in Hyperuricemic Mice
por: Li, Guozheng, et al.
Publicado: (2020)

Corrigendum: ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway
por: Shen, Yu-Li, et al.
Publicado: (2021)

Renoprotective Effect of the Recombinant Anti-IL-6R Fusion Proteins by Inhibiting JAK2/STAT3 Signaling Pathway in Diabetic Nephropathy
por: Zhang, Nanwen, et al.
Publicado: (2021)

Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy
por: Bao, Jinfang, et al.
Publicado: (2018)

Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment
por: Pan, Cheng, et al.
Publicado: (2020)

Suppression of NLRP3 Inflammasome by Erythropoietin via the EPOR/JAK2/STAT3 Pathway Contributes to Attenuation of Acute Lung Injury in Mice
por: Cao, Fei, et al.
Publicado: (2020)

Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of Parkin-Dependent Mitophagy
por: Zhang, Cong, et al.
Publicado: (2022)

Suppression of TGFβR-Smad3 pathway alleviates the syrinx induced by syringomyelia
por: Liu, Sumei, et al.
Publicado: (2023)

Atractylenolide I Induces Apoptosis and Suppresses Glycolysis by Blocking the JAK2/STAT3 Signaling Pathway in Colorectal Cancer Cells
por: Li, Yanxi, et al.
Publicado: (2020)

Suppression of NLRP3 Inflammasome by Dihydroarteannuin via the HIF‐1α and JAK3/STAT3 Signaling Pathway Contributes to Attenuation of Collagen-Induced Arthritis in Mice
por: Zhang, Mingying, et al.
Publicado: (2022)

Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway
por: Jiang, Jintao, et al.
Publicado: (2020)

The Anticancer Effects of Atractylenolide III Associate With the Downregulation of Jak3/Stat3-Dependent IDO Expression
por: Liu, Jun-bao, et al.
Publicado: (2020)

Zishen Qingre Tongluo Formula Improves Renal Fatty Acid Oxidation and Alleviated Fibrosis via the Regulation of the TGF-β1/Smad3 Signaling Pathway in Hyperuricemic Nephrology Rats
por: Liu, Peng, et al.
Publicado: (2021)

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy
por: Jiang, Mengjie, et al.
Publicado: (2019)

Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2016)

Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy via the TGF-β–Smad3 Pathway
por: Wang, Yinhui, et al.
Publicado: (2021)

Ginkgo biloba Extract Inhibits Astrocytic Lipocalin-2 Expression and Alleviates Neuroinflammatory Injury via the JAK2/STAT3 Pathway After Ischemic Brain Stroke
por: Zhang, Yehao, et al.
Publicado: (2018)

The mechanism of oxymatrine on atopic dermatitis in mice based on SOCS1/JAK-STAT3 pathway
por: Han, Xianwei, et al.
Publicado: (2023)

STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling
por: Wang, Gaohang, et al.
Publicado: (2015)

Fenofibrate Inhibits Subretinal Fibrosis Through Suppressing TGF‐β—Smad2/3 signaling and Wnt signaling in Neovascular Age‐Related Macular Degeneration
por: Chen, Qian, et al.
Publicado: (2020)

Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis
por: Zhao, Hai-Mei, et al.
Publicado: (2016)

Taxus wallichiana var. chinensis (Pilg.) Florin Aqueous Extract Suppresses the Proliferation and Metastasis in Lung Carcinoma via JAK/STAT3 Signaling Pathway
por: Sun, Leitao, et al.
Publicado: (2021)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Correction to: Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2018)

Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis
por: Wen, Ying, et al.
Publicado: (2023)

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade
por: Jung, Young Yun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_70s105e6u17avs5it03qvdutit