Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

BACKGROUND: While Alzheimer disease (AD) is generally considered as a brain disorder, blood biomarkers may be useful for the diagnosis and prediction of AD brain pathology. The APOE ε4 allele has shown cerebrovascular effects including acceleration of blood-brain barrier (BBB) breakdown. METHODS: We...

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Detalles Bibliográficos
Autores principales: Panitch, Rebecca, Hu, Junming, Xia, Weiming, Bennett, David A., Stein, Thor D., Farrer, Lindsay A., Jun, Gyungah R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830081/
https://www.ncbi.nlm.nih.gov/pubmed/35139885
http://dx.doi.org/10.1186/s13195-022-00975-z

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