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Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease

BACKGROUND: Accumulating α-synuclein (α-syn) aggregates in neurons and glial cells are the staples of many synucleinopathy disorders, such as Parkinson’s disease (PD). Since brain adenosine becomes greatly elevated in ageing brains and chronic adenosine A1 receptor (A1R) stimulation leads to neurode...

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Detalles Bibliográficos
Autores principales:	Jakova, Elisabet, Moutaoufik, Mohamed Taha, Lee, Jeremy S., Babu, Mohan, Cayabyab, Francisco S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830172/ https://www.ncbi.nlm.nih.gov/pubmed/35139916 http://dx.doi.org/10.1186/s40035-022-00284-3

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