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A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19

Neurological manifestations are common in SARS-CoV-2 infection, including life-threatening acute muscle weakness, due to neuromuscular disorders such as acute transverse myelitis (TM) and Guillain-Barré syndrome (GBS). These syndromes can rarely coexist and present as an overlap syndrome. Here, we r...

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Autores principales: Alrubaye, Riyadh, Bondugula, Vijayamala, Baleguli, Vidya, Chofor, Rosemary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830199/
https://www.ncbi.nlm.nih.gov/pubmed/35140089
http://dx.doi.org/10.1136/bcr-2021-246967
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author Alrubaye, Riyadh
Bondugula, Vijayamala
Baleguli, Vidya
Chofor, Rosemary
author_facet Alrubaye, Riyadh
Bondugula, Vijayamala
Baleguli, Vidya
Chofor, Rosemary
author_sort Alrubaye, Riyadh
collection PubMed
description Neurological manifestations are common in SARS-CoV-2 infection, including life-threatening acute muscle weakness, due to neuromuscular disorders such as acute transverse myelitis (TM) and Guillain-Barré syndrome (GBS). These syndromes can rarely coexist and present as an overlap syndrome. Here, we report a patient who developed acute symmetrical proximal lower limb weakness 5 days after diagnosis of COVID-19. GBS was diagnosed due to the presence of motor signs, albumin-cytological dissociation in cerebrospinal fluid examination and axonal damage according to nerve condition tests. However, abnormal areas on MRI of the thoracic spine and lack of improvement with intravenous immunoglobulin supported a diagnosis of TM. Therefore, a possible overlap between GBS and TM was established. To our knowledge, this is the third case report of GBS/TM overlap syndrome after COVID-19. The patient’s full and rapid recovery with intravenous corticosteroids and plasmapheresis supports our diagnosis.
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spelling pubmed-88301992022-02-22 A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19 Alrubaye, Riyadh Bondugula, Vijayamala Baleguli, Vidya Chofor, Rosemary BMJ Case Rep Case Reports: Rare disease Neurological manifestations are common in SARS-CoV-2 infection, including life-threatening acute muscle weakness, due to neuromuscular disorders such as acute transverse myelitis (TM) and Guillain-Barré syndrome (GBS). These syndromes can rarely coexist and present as an overlap syndrome. Here, we report a patient who developed acute symmetrical proximal lower limb weakness 5 days after diagnosis of COVID-19. GBS was diagnosed due to the presence of motor signs, albumin-cytological dissociation in cerebrospinal fluid examination and axonal damage according to nerve condition tests. However, abnormal areas on MRI of the thoracic spine and lack of improvement with intravenous immunoglobulin supported a diagnosis of TM. Therefore, a possible overlap between GBS and TM was established. To our knowledge, this is the third case report of GBS/TM overlap syndrome after COVID-19. The patient’s full and rapid recovery with intravenous corticosteroids and plasmapheresis supports our diagnosis. BMJ Publishing Group 2022-02-09 /pmc/articles/PMC8830199/ /pubmed/35140089 http://dx.doi.org/10.1136/bcr-2021-246967 Text en © BMJ Publishing Group Limited 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Rare disease
Alrubaye, Riyadh
Bondugula, Vijayamala
Baleguli, Vidya
Chofor, Rosemary
A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19
title A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19
title_full A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19
title_fullStr A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19
title_full_unstemmed A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19
title_short A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19
title_sort possible guillain-barré syndrome/transverse myelitis overlap syndrome after recent covid-19
topic Case Reports: Rare disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830199/
https://www.ncbi.nlm.nih.gov/pubmed/35140089
http://dx.doi.org/10.1136/bcr-2021-246967
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