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Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study
OBJECTIVE: To assess the long-term efficacy and safety of accelerated transepithelial corneal cross-linking (ATE-CXL) with 30 mW/cm(2) × 3 min. METHODS AND ANALYSIS: Thirty-four eyes of 23 patients with progressive keratoconus (KCN) recruited within a single centre were enrolled in this prospective...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830257/ https://www.ncbi.nlm.nih.gov/pubmed/35224204 http://dx.doi.org/10.1136/bmjophth-2021-000827 |
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author | Ishii, Hitoha Yoshida, Junko Toyono, Tetsuya Yamagami, Satoru Usui, Tomohiko Miyai, Takashi |
author_facet | Ishii, Hitoha Yoshida, Junko Toyono, Tetsuya Yamagami, Satoru Usui, Tomohiko Miyai, Takashi |
author_sort | Ishii, Hitoha |
collection | PubMed |
description | OBJECTIVE: To assess the long-term efficacy and safety of accelerated transepithelial corneal cross-linking (ATE-CXL) with 30 mW/cm(2) × 3 min. METHODS AND ANALYSIS: Thirty-four eyes of 23 patients with progressive keratoconus (KCN) recruited within a single centre were enrolled in this prospective interventional study. Exclusion criteria included: history of Descemet’s membrane rupture, glaucoma, uveitis, severe dry eye, concurrent corneal infections, and systemic disease that could affect corneal healing. ATE-CXL was performed with 3 min of ultraviolet-A continuous irradiation (30 mW/cm(2)). Follow-up examinations were scheduled on postoperative day 1; 1 and 2 weeks; 1, 3 and 6 months; and 1, 2 and 3 years. Main outcome measures were maximum corneal power (Kmax), average corneal power (AvgK), steepest corneal power (Ks), central corneal thickness, thinnest corneal thickness, uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BCVA) and endothelial cell density. RESULTS: Mean Kmax, AvgK, Ks, UCVA, BCVA and endothelial cell density did not significantly change over 3 years. The speed of progression obtained by linear regression analysis on corneal parameters (Kmax, AvgK, Ks) improved after ATE-CXL. All baseline parameters correlated with the postoperative Kmax slope. Two eyes underwent ATE-CXL redo because of continued progression after the primary CXL. CONCLUSION: This is the first report of 3-year results of ATE-CXL with 30 mW/cm(2) × 3 min. ATE-CXL (30 mW/cm(2) × 3 min) was safe and effective for slowing down KCN progression. TRIAL REGISTRATION NUMBER: This study was registered with ID UMIN000009372 in UMIN-Clinical Trials Registry. |
format | Online Article Text |
id | pubmed-8830257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-88302572022-02-24 Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study Ishii, Hitoha Yoshida, Junko Toyono, Tetsuya Yamagami, Satoru Usui, Tomohiko Miyai, Takashi BMJ Open Ophthalmol Cornea and Ocular Surface OBJECTIVE: To assess the long-term efficacy and safety of accelerated transepithelial corneal cross-linking (ATE-CXL) with 30 mW/cm(2) × 3 min. METHODS AND ANALYSIS: Thirty-four eyes of 23 patients with progressive keratoconus (KCN) recruited within a single centre were enrolled in this prospective interventional study. Exclusion criteria included: history of Descemet’s membrane rupture, glaucoma, uveitis, severe dry eye, concurrent corneal infections, and systemic disease that could affect corneal healing. ATE-CXL was performed with 3 min of ultraviolet-A continuous irradiation (30 mW/cm(2)). Follow-up examinations were scheduled on postoperative day 1; 1 and 2 weeks; 1, 3 and 6 months; and 1, 2 and 3 years. Main outcome measures were maximum corneal power (Kmax), average corneal power (AvgK), steepest corneal power (Ks), central corneal thickness, thinnest corneal thickness, uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BCVA) and endothelial cell density. RESULTS: Mean Kmax, AvgK, Ks, UCVA, BCVA and endothelial cell density did not significantly change over 3 years. The speed of progression obtained by linear regression analysis on corneal parameters (Kmax, AvgK, Ks) improved after ATE-CXL. All baseline parameters correlated with the postoperative Kmax slope. Two eyes underwent ATE-CXL redo because of continued progression after the primary CXL. CONCLUSION: This is the first report of 3-year results of ATE-CXL with 30 mW/cm(2) × 3 min. ATE-CXL (30 mW/cm(2) × 3 min) was safe and effective for slowing down KCN progression. TRIAL REGISTRATION NUMBER: This study was registered with ID UMIN000009372 in UMIN-Clinical Trials Registry. BMJ Publishing Group 2022-02-08 /pmc/articles/PMC8830257/ /pubmed/35224204 http://dx.doi.org/10.1136/bmjophth-2021-000827 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Cornea and Ocular Surface Ishii, Hitoha Yoshida, Junko Toyono, Tetsuya Yamagami, Satoru Usui, Tomohiko Miyai, Takashi Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study |
title | Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study |
title_full | Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study |
title_fullStr | Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study |
title_full_unstemmed | Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study |
title_short | Three-year results of accelerated transepithelial cross-linking (30 mW/cm(2) × 3 min) for keratoconus: a prospective study |
title_sort | three-year results of accelerated transepithelial cross-linking (30 mw/cm(2) × 3 min) for keratoconus: a prospective study |
topic | Cornea and Ocular Surface |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830257/ https://www.ncbi.nlm.nih.gov/pubmed/35224204 http://dx.doi.org/10.1136/bmjophth-2021-000827 |
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