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Scoping review of evidence for managing postnatal hypoglycaemia

OBJECTIVES: To identify what is known empirically about the screening, treatment and harm of exposure to neonatal hypoglycaemia. DESIGN: Scoping review that applied a preregistered protocol based on established frameworks. DATA SOURCES: Medline and Embase, up to 12 May 2020. STUDY SELECTION: Compara...

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Autores principales: Horwitz, Jennifer, Mardiros, Linda, Musa, Ahmed, Welch, Vivian A, Hodgson, Amanda, Narvey, Michael, Ghazzawi, Andrea, Shea, Beverley, Saginur, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830267/
https://www.ncbi.nlm.nih.gov/pubmed/35135768
http://dx.doi.org/10.1136/bmjopen-2021-053047
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author Horwitz, Jennifer
Mardiros, Linda
Musa, Ahmed
Welch, Vivian A
Hodgson, Amanda
Narvey, Michael
Ghazzawi, Andrea
Shea, Beverley
Saginur, Michael
author_facet Horwitz, Jennifer
Mardiros, Linda
Musa, Ahmed
Welch, Vivian A
Hodgson, Amanda
Narvey, Michael
Ghazzawi, Andrea
Shea, Beverley
Saginur, Michael
author_sort Horwitz, Jennifer
collection PubMed
description OBJECTIVES: To identify what is known empirically about the screening, treatment and harm of exposure to neonatal hypoglycaemia. DESIGN: Scoping review that applied a preregistered protocol based on established frameworks. DATA SOURCES: Medline and Embase, up to 12 May 2020. STUDY SELECTION: Comparative and case-series studies, as well as guidelines, published in English or French, on the topic of immediate inpatient postnatal glucose screening in newborns. DATA GATHERING: Article selection and characterisation were performed in duplicate using predefined data extraction forms specific to primary studies and guidelines. RESULTS: 12 guidelines and 74 primary studies were included. A neurodevelopmental outcome was primary in 32 studies: 30 observational studies followed up posthypoglycaemic, and the 2 intervention studies included 1 randomised controlled trial (RCT) about treatment thresholds. Three other RCTs assessed dextrose gel (two) and oral sucrose (one). 12 of 30 studies that evaluated non-neurodevelopmental primary outcomes were intervention studies. Only one cohort study compared outcomes in screened vs unscreened newborns. The guidelines did not arrive at a consensus definition of postnatal hypoglycaemic, and addressed potential harms of screening more often than primary studies. CONCLUSIONS: The primary literature that informs hypoglycaemia screening is a series of studies that relate neurodevelopmental outcomes to postnatal hypoglycaemia. Further research is needed to better define an optimal threshold for hypoglycaemia that warrants intervention, based on long-term neurodevelopmental outcomes and a better delineation of potential screening harms.
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spelling pubmed-88302672022-02-24 Scoping review of evidence for managing postnatal hypoglycaemia Horwitz, Jennifer Mardiros, Linda Musa, Ahmed Welch, Vivian A Hodgson, Amanda Narvey, Michael Ghazzawi, Andrea Shea, Beverley Saginur, Michael BMJ Open Paediatrics OBJECTIVES: To identify what is known empirically about the screening, treatment and harm of exposure to neonatal hypoglycaemia. DESIGN: Scoping review that applied a preregistered protocol based on established frameworks. DATA SOURCES: Medline and Embase, up to 12 May 2020. STUDY SELECTION: Comparative and case-series studies, as well as guidelines, published in English or French, on the topic of immediate inpatient postnatal glucose screening in newborns. DATA GATHERING: Article selection and characterisation were performed in duplicate using predefined data extraction forms specific to primary studies and guidelines. RESULTS: 12 guidelines and 74 primary studies were included. A neurodevelopmental outcome was primary in 32 studies: 30 observational studies followed up posthypoglycaemic, and the 2 intervention studies included 1 randomised controlled trial (RCT) about treatment thresholds. Three other RCTs assessed dextrose gel (two) and oral sucrose (one). 12 of 30 studies that evaluated non-neurodevelopmental primary outcomes were intervention studies. Only one cohort study compared outcomes in screened vs unscreened newborns. The guidelines did not arrive at a consensus definition of postnatal hypoglycaemic, and addressed potential harms of screening more often than primary studies. CONCLUSIONS: The primary literature that informs hypoglycaemia screening is a series of studies that relate neurodevelopmental outcomes to postnatal hypoglycaemia. Further research is needed to better define an optimal threshold for hypoglycaemia that warrants intervention, based on long-term neurodevelopmental outcomes and a better delineation of potential screening harms. BMJ Publishing Group 2022-02-08 /pmc/articles/PMC8830267/ /pubmed/35135768 http://dx.doi.org/10.1136/bmjopen-2021-053047 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Paediatrics
Horwitz, Jennifer
Mardiros, Linda
Musa, Ahmed
Welch, Vivian A
Hodgson, Amanda
Narvey, Michael
Ghazzawi, Andrea
Shea, Beverley
Saginur, Michael
Scoping review of evidence for managing postnatal hypoglycaemia
title Scoping review of evidence for managing postnatal hypoglycaemia
title_full Scoping review of evidence for managing postnatal hypoglycaemia
title_fullStr Scoping review of evidence for managing postnatal hypoglycaemia
title_full_unstemmed Scoping review of evidence for managing postnatal hypoglycaemia
title_short Scoping review of evidence for managing postnatal hypoglycaemia
title_sort scoping review of evidence for managing postnatal hypoglycaemia
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830267/
https://www.ncbi.nlm.nih.gov/pubmed/35135768
http://dx.doi.org/10.1136/bmjopen-2021-053047
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