Cargando…

Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis

The intensity of a pathogen infection plays a key role in determining how the host responds to infection. Hosts with high infections are more likely to transmit infection to others, and are may be more likely to experience progression from infection to disease symptoms, to being physiologically comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Bielby, Jon, Sausor, Cristina, Monsalve-Carcaño, Camino, Bosch, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830297/
https://www.ncbi.nlm.nih.gov/pubmed/35186480
http://dx.doi.org/10.7717/peerj.12889
_version_ 1784648245300953088
author Bielby, Jon
Sausor, Cristina
Monsalve-Carcaño, Camino
Bosch, Jaime
author_facet Bielby, Jon
Sausor, Cristina
Monsalve-Carcaño, Camino
Bosch, Jaime
author_sort Bielby, Jon
collection PubMed
description The intensity of a pathogen infection plays a key role in determining how the host responds to infection. Hosts with high infections are more likely to transmit infection to others, and are may be more likely to experience progression from infection to disease symptoms, to being physiologically compromised by disease. Understanding how and why hosts exhibit variation in infection intensity therefore plays a major part in developing and implementing measures aimed at controlling infection spread, its effects, and its chance of persisting and circulating within a population of hosts. To track the relative importance of a number of variables in determining the level of infection intensity, we ran field-surveys at two breeding sites over a 12 month period using marked larvae of the common midwife toad (Alyes obstetricans) and their levels of infection with the amphibian pathogen Batrachochytrium dendrobatidis (Bd). At each sampling occasion we measured the density of larvae, the temperature of the water in the 48 h prior to sampling, the period of time the sampled individual had been in the water body, the developmental (Gosner) stage and the intensity of Bd infection of the individual. Overall our data suggest that the temperature and the duration of time spent in the water play a major role in determining the intensity of Bd infection within an individual host. However, although the duration of time spent in the water was clearly associated with infection intensity, the relationship was negative: larvae that had spent less than 3–6 months in the water had significantly higher infection intensities than those that had spent over 12 months, although this infection intensity peaked between 9 and 12 months. This could be due to animals with heavier infections developing more quickly, suffering increased mortality or, more likely, losing their mouthparts (the only part of anuran larvae that can be infected with Bd). Overall, our results identify drivers of infection intensity, and potentially transmissibility and spread, and we attribute these differences to both host and pathogen biology.
format Online
Article
Text
id pubmed-8830297
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher PeerJ Inc.
record_format MEDLINE/PubMed
spelling pubmed-88302972022-02-17 Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis Bielby, Jon Sausor, Cristina Monsalve-Carcaño, Camino Bosch, Jaime PeerJ Conservation Biology The intensity of a pathogen infection plays a key role in determining how the host responds to infection. Hosts with high infections are more likely to transmit infection to others, and are may be more likely to experience progression from infection to disease symptoms, to being physiologically compromised by disease. Understanding how and why hosts exhibit variation in infection intensity therefore plays a major part in developing and implementing measures aimed at controlling infection spread, its effects, and its chance of persisting and circulating within a population of hosts. To track the relative importance of a number of variables in determining the level of infection intensity, we ran field-surveys at two breeding sites over a 12 month period using marked larvae of the common midwife toad (Alyes obstetricans) and their levels of infection with the amphibian pathogen Batrachochytrium dendrobatidis (Bd). At each sampling occasion we measured the density of larvae, the temperature of the water in the 48 h prior to sampling, the period of time the sampled individual had been in the water body, the developmental (Gosner) stage and the intensity of Bd infection of the individual. Overall our data suggest that the temperature and the duration of time spent in the water play a major role in determining the intensity of Bd infection within an individual host. However, although the duration of time spent in the water was clearly associated with infection intensity, the relationship was negative: larvae that had spent less than 3–6 months in the water had significantly higher infection intensities than those that had spent over 12 months, although this infection intensity peaked between 9 and 12 months. This could be due to animals with heavier infections developing more quickly, suffering increased mortality or, more likely, losing their mouthparts (the only part of anuran larvae that can be infected with Bd). Overall, our results identify drivers of infection intensity, and potentially transmissibility and spread, and we attribute these differences to both host and pathogen biology. PeerJ Inc. 2022-02-07 /pmc/articles/PMC8830297/ /pubmed/35186480 http://dx.doi.org/10.7717/peerj.12889 Text en © 2022 Bielby et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Conservation Biology
Bielby, Jon
Sausor, Cristina
Monsalve-Carcaño, Camino
Bosch, Jaime
Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis
title Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis
title_full Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis
title_fullStr Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis
title_full_unstemmed Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis
title_short Temperature and duration of exposure drive infection intensity with the amphibian pathogen Batrachochytrium dendrobatidis
title_sort temperature and duration of exposure drive infection intensity with the amphibian pathogen batrachochytrium dendrobatidis
topic Conservation Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830297/
https://www.ncbi.nlm.nih.gov/pubmed/35186480
http://dx.doi.org/10.7717/peerj.12889
work_keys_str_mv AT bielbyjon temperatureanddurationofexposuredriveinfectionintensitywiththeamphibianpathogenbatrachochytriumdendrobatidis
AT sausorcristina temperatureanddurationofexposuredriveinfectionintensitywiththeamphibianpathogenbatrachochytriumdendrobatidis
AT monsalvecarcanocamino temperatureanddurationofexposuredriveinfectionintensitywiththeamphibianpathogenbatrachochytriumdendrobatidis
AT boschjaime temperatureanddurationofexposuredriveinfectionintensitywiththeamphibianpathogenbatrachochytriumdendrobatidis