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Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy

Increasing evidence supports targeting the adenosine pathway in immuno-oncology with several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and CD39 in development. Through a cyclic-AMP-mediated intracellular cascade, adenosine shifts the cytokine and cellular profile of the...

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Detalles Bibliográficos
Autores principales:	Augustin, Ryan C., Leone, Robert D., Naing, Aung, Fong, Lawrence, Bao, Riyue, Luke, Jason J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830302/ https://www.ncbi.nlm.nih.gov/pubmed/35135866 http://dx.doi.org/10.1136/jitc-2021-004089

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