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Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness

OBJECTIVE: Disorder of consciousness (DoC) resulting from severe brain injury is characterized by cortical and subcortical dysconnectivity. However, research on seed-based effective connectivity (EC) of DoC might be questioned as to the heterogeneity of prior assumptions. METHODS: Functional MRI dat...

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Autores principales: Chen, Linglong, Rao, Bo, Li, Sirui, Gao, Lei, Xie, Yu, Dai, Xuan, Fu, Kai, Peng, Xu Zhi, Xu, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830329/
https://www.ncbi.nlm.nih.gov/pubmed/35153656
http://dx.doi.org/10.3389/fnins.2021.766633
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author Chen, Linglong
Rao, Bo
Li, Sirui
Gao, Lei
Xie, Yu
Dai, Xuan
Fu, Kai
Peng, Xu Zhi
Xu, Haibo
author_facet Chen, Linglong
Rao, Bo
Li, Sirui
Gao, Lei
Xie, Yu
Dai, Xuan
Fu, Kai
Peng, Xu Zhi
Xu, Haibo
author_sort Chen, Linglong
collection PubMed
description OBJECTIVE: Disorder of consciousness (DoC) resulting from severe brain injury is characterized by cortical and subcortical dysconnectivity. However, research on seed-based effective connectivity (EC) of DoC might be questioned as to the heterogeneity of prior assumptions. METHODS: Functional MRI data of 16 DoC patients and 16 demographically matched healthy individuals were analyzed. Revised coma recovery scale (CRS-R) scores of patients were acquired. Seed-based d mapping permutation of subject images (SDM-PSI) of meta-analysis was performed to quantitatively synthesize results from neuroimaging studies that evaluated resting-state functional activity in DoC patients. Spectral dynamic causal modeling (spDCM) was used to assess how EC altered between brain regions in DoC patients compared to healthy individuals. RESULTS: We found increased effective connectivity in left striatum and decreased effective connectivity in bilateral precuneus (preCUN)/posterior cingulate cortex (PCC), bilateral midcingulate cortex and left middle frontal gyrus in DoC compared with the healthy controls. The resulting pattern of interaction in DoC indicated disrupted connection and disturbance of posterior parietal-frontal-striatum, and reduced self-inhibition of preCUN/PCC. The strength of self-inhibition of preCUN/PCC was negatively correlated with the total score of CRS-R. CONCLUSION: This impaired EC in DoC may underlie disruption in the posterior parietal-frontal-striatum circuit, particularly damage to the cortico-striatal connection and possible loss of preCUN/PCC function as the main regulatory hub.
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spelling pubmed-88303292022-02-11 Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness Chen, Linglong Rao, Bo Li, Sirui Gao, Lei Xie, Yu Dai, Xuan Fu, Kai Peng, Xu Zhi Xu, Haibo Front Neurosci Neuroscience OBJECTIVE: Disorder of consciousness (DoC) resulting from severe brain injury is characterized by cortical and subcortical dysconnectivity. However, research on seed-based effective connectivity (EC) of DoC might be questioned as to the heterogeneity of prior assumptions. METHODS: Functional MRI data of 16 DoC patients and 16 demographically matched healthy individuals were analyzed. Revised coma recovery scale (CRS-R) scores of patients were acquired. Seed-based d mapping permutation of subject images (SDM-PSI) of meta-analysis was performed to quantitatively synthesize results from neuroimaging studies that evaluated resting-state functional activity in DoC patients. Spectral dynamic causal modeling (spDCM) was used to assess how EC altered between brain regions in DoC patients compared to healthy individuals. RESULTS: We found increased effective connectivity in left striatum and decreased effective connectivity in bilateral precuneus (preCUN)/posterior cingulate cortex (PCC), bilateral midcingulate cortex and left middle frontal gyrus in DoC compared with the healthy controls. The resulting pattern of interaction in DoC indicated disrupted connection and disturbance of posterior parietal-frontal-striatum, and reduced self-inhibition of preCUN/PCC. The strength of self-inhibition of preCUN/PCC was negatively correlated with the total score of CRS-R. CONCLUSION: This impaired EC in DoC may underlie disruption in the posterior parietal-frontal-striatum circuit, particularly damage to the cortico-striatal connection and possible loss of preCUN/PCC function as the main regulatory hub. Frontiers Media S.A. 2022-01-20 /pmc/articles/PMC8830329/ /pubmed/35153656 http://dx.doi.org/10.3389/fnins.2021.766633 Text en Copyright © 2022 Chen, Rao, Li, Gao, Xie, Dai, Fu, Peng and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chen, Linglong
Rao, Bo
Li, Sirui
Gao, Lei
Xie, Yu
Dai, Xuan
Fu, Kai
Peng, Xu Zhi
Xu, Haibo
Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness
title Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness
title_full Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness
title_fullStr Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness
title_full_unstemmed Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness
title_short Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness
title_sort altered effective connectivity measured by resting-state functional magnetic resonance imaging in posterior parietal-frontal-striatum circuit in patients with disorder of consciousness
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830329/
https://www.ncbi.nlm.nih.gov/pubmed/35153656
http://dx.doi.org/10.3389/fnins.2021.766633
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