Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3

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Macrophages display phenotypic plasticity and can be induced by hepatitis B virus (HBV) to undergo either M1-like pro-inflammatory or M2-like anti-inflammatory polarization. Here, we report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-...

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Detalles Bibliográficos
Autores principales: Li, Yumei, Zhu, Yanwen, Feng, Shu, Ishida, Yuji, Chiu, Tsu-Pei, Saito, Takeshi, Wang, Sean, Ann, David K., Ou, Jing-hsiung James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830375/
https://www.ncbi.nlm.nih.gov/pubmed/35081341
http://dx.doi.org/10.1016/j.celrep.2021.110284
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