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Small Fiber Neuropathy in Sarcoidosis

Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains significantly understudied. This study aimed to identify the clinical...

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Autores principales: Gavrilova, Natalia, Starshinova, Anna, Zinchenko, Yulia, Kudlay, Dmitry, Shapkina, Valeria, Malkova, Anna, Belyaeva, Ekaterina, Pavlova, Maria, Yablonskiy, Piotr, Shoenfeld, Yehuda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830461/
https://www.ncbi.nlm.nih.gov/pubmed/35366250
http://dx.doi.org/10.3390/pathophysiology28040035
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author Gavrilova, Natalia
Starshinova, Anna
Zinchenko, Yulia
Kudlay, Dmitry
Shapkina, Valeria
Malkova, Anna
Belyaeva, Ekaterina
Pavlova, Maria
Yablonskiy, Piotr
Shoenfeld, Yehuda
author_facet Gavrilova, Natalia
Starshinova, Anna
Zinchenko, Yulia
Kudlay, Dmitry
Shapkina, Valeria
Malkova, Anna
Belyaeva, Ekaterina
Pavlova, Maria
Yablonskiy, Piotr
Shoenfeld, Yehuda
author_sort Gavrilova, Natalia
collection PubMed
description Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains significantly understudied. This study aimed to identify the clinical and histological correlates of small fiber neuropathy in sarcoidosis patients. The study was performed in 2018–2019 yy and included 50 patients with pulmonary sarcoidosis (n = 25) and healthy subjects (n = 25). For the clinical verification of the SFN, the “Small Fiber Neuropathy Screening List” (SFN-SL) was used. A punch biopsy of the skin was performed followed by enzyme immunoassay analysis with PGP 9.5 antibodies. Up to 60% of the sarcoidosis patients reported the presence of at least one complaint, and it was possible that these complaints were associated with SFN. The most frequent complaints included dysfunctions of the cardiovascular and musculoskeletal systems and the gastrointestinal tract. A negative, statistically significant correlation between the intraepidermal nerve fiber density (IEND) and SFN-SL score was revealed. In patients with pulmonary sarcoidosis, small fiber neuropathy might develop as a result of systemic immune-mediated inflammation. The most common symptoms of this complication were dysautonomia and mild sensory dysfunction.
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spelling pubmed-88304612022-03-23 Small Fiber Neuropathy in Sarcoidosis Gavrilova, Natalia Starshinova, Anna Zinchenko, Yulia Kudlay, Dmitry Shapkina, Valeria Malkova, Anna Belyaeva, Ekaterina Pavlova, Maria Yablonskiy, Piotr Shoenfeld, Yehuda Pathophysiology Article Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains significantly understudied. This study aimed to identify the clinical and histological correlates of small fiber neuropathy in sarcoidosis patients. The study was performed in 2018–2019 yy and included 50 patients with pulmonary sarcoidosis (n = 25) and healthy subjects (n = 25). For the clinical verification of the SFN, the “Small Fiber Neuropathy Screening List” (SFN-SL) was used. A punch biopsy of the skin was performed followed by enzyme immunoassay analysis with PGP 9.5 antibodies. Up to 60% of the sarcoidosis patients reported the presence of at least one complaint, and it was possible that these complaints were associated with SFN. The most frequent complaints included dysfunctions of the cardiovascular and musculoskeletal systems and the gastrointestinal tract. A negative, statistically significant correlation between the intraepidermal nerve fiber density (IEND) and SFN-SL score was revealed. In patients with pulmonary sarcoidosis, small fiber neuropathy might develop as a result of systemic immune-mediated inflammation. The most common symptoms of this complication were dysautonomia and mild sensory dysfunction. MDPI 2021-12-20 /pmc/articles/PMC8830461/ /pubmed/35366250 http://dx.doi.org/10.3390/pathophysiology28040035 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gavrilova, Natalia
Starshinova, Anna
Zinchenko, Yulia
Kudlay, Dmitry
Shapkina, Valeria
Malkova, Anna
Belyaeva, Ekaterina
Pavlova, Maria
Yablonskiy, Piotr
Shoenfeld, Yehuda
Small Fiber Neuropathy in Sarcoidosis
title Small Fiber Neuropathy in Sarcoidosis
title_full Small Fiber Neuropathy in Sarcoidosis
title_fullStr Small Fiber Neuropathy in Sarcoidosis
title_full_unstemmed Small Fiber Neuropathy in Sarcoidosis
title_short Small Fiber Neuropathy in Sarcoidosis
title_sort small fiber neuropathy in sarcoidosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830461/
https://www.ncbi.nlm.nih.gov/pubmed/35366250
http://dx.doi.org/10.3390/pathophysiology28040035
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