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Small Fiber Neuropathy in Sarcoidosis
Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains significantly understudied. This study aimed to identify the clinical...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830461/ https://www.ncbi.nlm.nih.gov/pubmed/35366250 http://dx.doi.org/10.3390/pathophysiology28040035 |
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author | Gavrilova, Natalia Starshinova, Anna Zinchenko, Yulia Kudlay, Dmitry Shapkina, Valeria Malkova, Anna Belyaeva, Ekaterina Pavlova, Maria Yablonskiy, Piotr Shoenfeld, Yehuda |
author_facet | Gavrilova, Natalia Starshinova, Anna Zinchenko, Yulia Kudlay, Dmitry Shapkina, Valeria Malkova, Anna Belyaeva, Ekaterina Pavlova, Maria Yablonskiy, Piotr Shoenfeld, Yehuda |
author_sort | Gavrilova, Natalia |
collection | PubMed |
description | Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains significantly understudied. This study aimed to identify the clinical and histological correlates of small fiber neuropathy in sarcoidosis patients. The study was performed in 2018–2019 yy and included 50 patients with pulmonary sarcoidosis (n = 25) and healthy subjects (n = 25). For the clinical verification of the SFN, the “Small Fiber Neuropathy Screening List” (SFN-SL) was used. A punch biopsy of the skin was performed followed by enzyme immunoassay analysis with PGP 9.5 antibodies. Up to 60% of the sarcoidosis patients reported the presence of at least one complaint, and it was possible that these complaints were associated with SFN. The most frequent complaints included dysfunctions of the cardiovascular and musculoskeletal systems and the gastrointestinal tract. A negative, statistically significant correlation between the intraepidermal nerve fiber density (IEND) and SFN-SL score was revealed. In patients with pulmonary sarcoidosis, small fiber neuropathy might develop as a result of systemic immune-mediated inflammation. The most common symptoms of this complication were dysautonomia and mild sensory dysfunction. |
format | Online Article Text |
id | pubmed-8830461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88304612022-03-23 Small Fiber Neuropathy in Sarcoidosis Gavrilova, Natalia Starshinova, Anna Zinchenko, Yulia Kudlay, Dmitry Shapkina, Valeria Malkova, Anna Belyaeva, Ekaterina Pavlova, Maria Yablonskiy, Piotr Shoenfeld, Yehuda Pathophysiology Article Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains significantly understudied. This study aimed to identify the clinical and histological correlates of small fiber neuropathy in sarcoidosis patients. The study was performed in 2018–2019 yy and included 50 patients with pulmonary sarcoidosis (n = 25) and healthy subjects (n = 25). For the clinical verification of the SFN, the “Small Fiber Neuropathy Screening List” (SFN-SL) was used. A punch biopsy of the skin was performed followed by enzyme immunoassay analysis with PGP 9.5 antibodies. Up to 60% of the sarcoidosis patients reported the presence of at least one complaint, and it was possible that these complaints were associated with SFN. The most frequent complaints included dysfunctions of the cardiovascular and musculoskeletal systems and the gastrointestinal tract. A negative, statistically significant correlation between the intraepidermal nerve fiber density (IEND) and SFN-SL score was revealed. In patients with pulmonary sarcoidosis, small fiber neuropathy might develop as a result of systemic immune-mediated inflammation. The most common symptoms of this complication were dysautonomia and mild sensory dysfunction. MDPI 2021-12-20 /pmc/articles/PMC8830461/ /pubmed/35366250 http://dx.doi.org/10.3390/pathophysiology28040035 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gavrilova, Natalia Starshinova, Anna Zinchenko, Yulia Kudlay, Dmitry Shapkina, Valeria Malkova, Anna Belyaeva, Ekaterina Pavlova, Maria Yablonskiy, Piotr Shoenfeld, Yehuda Small Fiber Neuropathy in Sarcoidosis |
title | Small Fiber Neuropathy in Sarcoidosis |
title_full | Small Fiber Neuropathy in Sarcoidosis |
title_fullStr | Small Fiber Neuropathy in Sarcoidosis |
title_full_unstemmed | Small Fiber Neuropathy in Sarcoidosis |
title_short | Small Fiber Neuropathy in Sarcoidosis |
title_sort | small fiber neuropathy in sarcoidosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830461/ https://www.ncbi.nlm.nih.gov/pubmed/35366250 http://dx.doi.org/10.3390/pathophysiology28040035 |
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