Cargando…

New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights

An efficient atom-economical synthetic protocol to access new imidazole-based N-phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized to provide a series of N-phenylbenzamide derivatives in a short reaction time (2–4 h) with an 80–85% yield. The cytotoxic evaluati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malik, M. Shaheer, Alsantali, Reem I., Jamal, Qazi Mohammad Sajid, Seddigi, Zaki S., Morad, Moataz, Alsharif, Meshari A., Hussein, Essam M., Jassas, Rabab S., Al-Rooqi, Munirah M., Abduljaleel, Zainularifeen, Babalgith, Ahmed O., Altass, Hatem M., Moussa, Ziad, Ahmed, Saleh A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830504/ https://www.ncbi.nlm.nih.gov/pubmed/35155379 http://dx.doi.org/10.3389/fchem.2021.808556

Ejemplares similares

Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies
por: Malik, M. Shaheer, et al.
Publicado: (2021)

Journey of anthraquinones as anticancer agents – a systematic review of recent literature
por: Malik, M. Shaheer, et al.
Publicado: (2021)

High-Efficacy Hierarchical Dy(2)O(3)/TiO(2) Nanoflower toward Wastewater Reclamation: A Combined Photoelectrochemical and Photocatalytic Strategy
por: Kaid, Mahmoud M., et al.
Publicado: (2022)

Scholl reaction as a powerful tool for the synthesis of nanographenes: a systematic review
por: Jassas, Rabab S., et al.
Publicado: (2021)

Current status of N-, O-, S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview
por: Jassas, Rabab S., et al.
Publicado: (2023)

Combating Essential Metal Toxicity: Key Information from Optical Spectroscopy
por: Ahmed, Saleh A., et al.
Publicado: (2020)

Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights
por: Malik, M. Shaheer, et al.
Publicado: (2023)

Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents
por: Hussein, Essam M., et al.
Publicado: (2020)

Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies
por: Mehmood, Rabia, et al.
Publicado: (2022)

Evaluation of 2,3-Dihydro-1,5-benzothiazepine Derivatives as Potential Tyrosinase Inhibitors: In Vitro and In Silico Studies
por: Al-Rooqi, Munirah M., et al.
Publicado: (2023)

Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
por: Obaid, Rami J., et al.
Publicado: (2022)

Monoclonal antibody designed for SARS-nCoV-2 spike protein of receptor binding domain on antigenic targeted epitopes for inhibition to prevent viral entry
por: Abduljaleel, Zainularifeen, et al.
Publicado: (2022)

DDQ as a versatile and easily recyclable oxidant: a systematic review
por: Alsharif, Meshari A., et al.
Publicado: (2021)

Rational Design and Synthesis of Naphthalene Diimide Linked Bis-Naphthalimides as DNA Interactive Agents
por: Malik, M. Shaheer, et al.
Publicado: (2021)

2-Methyl-N-phenylbenzamide
por: Gowda, B. Thimme, et al.
Publicado: (2008)

4-Bromo-N-phenylbenzamide
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

4-Chloro-N-phenylbenzamide
por: Rodrigues, Vinola Z., et al.
Publicado: (2011)

3-Chloro-N-phenylbenzamide
por: Rodrigues, Vinola Z., et al.
Publicado: (2011)

3-Methyl-N-phenylbenzamide
por: Gowda, B. Thimme, et al.
Publicado: (2008)

Design, synthesis, and biological evaluation of novel N(4)-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors
por: Hussein, Essam M., et al.
Publicado: (2019)

2,6-Dichloro-N-phenylbenzamide
por: Liu, Hui, et al.
Publicado: (2011)

2-Hydroxy-5-nitro-N-phenylbenzamide
por: Raza, Abdul Rauf, et al.
Publicado: (2010)

Structural and Functional Analysis of human lung cancer risk associated hOGG1 variant Ser326Cys in DNA repair gene by molecular dynamics simulation
por: Abduljaleel, Zainularifeen
Publicado: (2019)

Comprehensive structure-function analysis of causative variants in retinal pigment epithelium specific 65 kDa protein associated Leber Congenital Amaurosis
por: Abduljaleel, Zainularifeen
Publicado: (2019)

2-Hydroxy-3-nitro-N-phenylbenzamide
por: Raza, Abdul Rauf, et al.
Publicado: (2009)

2-Anilino-N-methyl-N-phenylbenzamide
por: Yang, Xing-Xing, et al.
Publicado: (2009)

2-Chloro-4-fluoro-N-phenylbenzamide
por: Tan, Zhengde, et al.
Publicado: (2009)

4-Anilino-3-nitro-N-phenylbenzamide
por: Chen, Guihua, et al.
Publicado: (2010)

Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review
por: Obaid, Rami J., et al.
Publicado: (2021)

Crystal structure of 4-methoxy-N-phenylbenzamide
por: Wang, Zhijun, et al.
Publicado: (2014)

2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase
por: Krátký, Martin, et al.
Publicado: (2019)

Synthesis, In Silico Study, Antibacterial and Antifungal Activities of N-phenylbenzamides
por: Sulistyowaty, Melanny Ika, et al.
Publicado: (2023)

Structural analysis of 2-iodobenzamide and 2-iodo-N-phenylbenzamide
por: Bairagi, Keshab M., et al.
Publicado: (2018)

Implementation of surface functionalization of MnS nanoparticles for achieving novel optical properties and improving therapeutic potential
por: Bera, Arpan, et al.
Publicado: (2022)

A spectroscopy based prototype for the noninvasive detection of diabetes from human saliva using nanohybrids acting as nanozyme
por: Roy, Lopamudra, et al.
Publicado: (2023)

Antibacterial Properties and Computational Insights of Potent Novel Linezolid-Based Oxazolidinones
por: Malik, M. Shaheer, et al.
Publicado: (2023)

Carbonate Doping in TiO(2) Microsphere: The Key Parameter Influencing Others for Efficient Dye Sensitized Solar Cell
por: Seddigi, Zaki S., et al.
Publicado: (2016)

Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites
por: Nué-Martinez, J. Jonathan, et al.
Publicado: (2023)

In Silico Screening and Molecular Dynamics Simulation Studies in the Identification of Natural Compound Inhibitors Targeting the Human Norovirus RdRp Protein to Fight Gastroenteritis
por: Obaid, Rami J., et al.
Publicado: (2023)

Nano-MOFs as targeted drug delivery agents to combat antibiotic-resistant bacterial infections
por: Ahmed, Saleh A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_550t97i8ofrpo71m0cmvlcqird