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Absence of signal peptide peptidase in peripheral sensory neurons affects latency-reactivation in HSV-1 ocularly infected mice

We previously reported that HSV-1 infectivity in vitro and in vivo requires HSV glycoprotein K (gK) binding to the ER signal peptide peptidase (SPP). Anterograde-retrograde transport via peripheral nerves between the site of infection (i.e., eye) and the site of latency (neurons) is a critical proce...

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Detalles Bibliográficos
Autores principales:	Wang, Shaohui, Jaggi, Ujjaldeep, Tormanen, Kati, Hirose, Satoshi, Ghiasi, Homayon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830783/ https://www.ncbi.nlm.nih.gov/pubmed/35100323 http://dx.doi.org/10.1371/journal.ppat.1010281

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