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Differential Cognitive Performance in Females and Males with Regular Cannabis Use

OBJECTIVES: Preclinical and clinical studies suggest that males and females may be differentially affected by cannabis use. This study evaluated the interaction of cannabis use and biological sex on cognition, and the association between observed cognitive deficits and features of cannabis use. METH...

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Autores principales: Martin, Ashley M. Schnakenberg, D’Souza, Deepak Cyril, Newman, Sharlene D., Hetrick, William P., O’Donnell, Brian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830784/
https://www.ncbi.nlm.nih.gov/pubmed/34261548
http://dx.doi.org/10.1017/S1355617721000606
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author Martin, Ashley M. Schnakenberg
D’Souza, Deepak Cyril
Newman, Sharlene D.
Hetrick, William P.
O’Donnell, Brian F.
author_facet Martin, Ashley M. Schnakenberg
D’Souza, Deepak Cyril
Newman, Sharlene D.
Hetrick, William P.
O’Donnell, Brian F.
author_sort Martin, Ashley M. Schnakenberg
collection PubMed
description OBJECTIVES: Preclinical and clinical studies suggest that males and females may be differentially affected by cannabis use. This study evaluated the interaction of cannabis use and biological sex on cognition, and the association between observed cognitive deficits and features of cannabis use. METHODS: Cognitive measures were assessed in those with regular, ongoing, cannabis use (N = 40; 22 female) and non-using peers (N = 40; 23 female). Intelligence, psychomotor speed, and verbal working memory were measured with the Wechsler Abbreviated Scale of Intelligence, Digit Symbol Test, and Digit Span and Hopkins Verbal Learning Test, respectively. Associations between cognitive measures and cannabis use features (e.g., lifetime cannabis use, age of initiation, time since last use of cannabis, recent high-concentration tetrahydrocannabinoid exposure) were also evaluated. RESULTS: No main effects of group were observed across measures. Significant interactions between group and biological sex were observed on measures of intelligence, psychomotor speed, and verbal learning, with greatest group differences observed between males with and without regular cannabis use. Psychomotor performance was negatively correlated with lifetime cannabis exposure. Female and male cannabis use groups did not differ in features of cannabis use. CONCLUSIONS: Findings suggest that biological sex influences the relationship between cannabis and cognition, with males potentially being more vulnerable to the neurocognitive deficits related to cannabis use.
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spelling pubmed-88307842022-02-10 Differential Cognitive Performance in Females and Males with Regular Cannabis Use Martin, Ashley M. Schnakenberg D’Souza, Deepak Cyril Newman, Sharlene D. Hetrick, William P. O’Donnell, Brian F. J Int Neuropsychol Soc Article OBJECTIVES: Preclinical and clinical studies suggest that males and females may be differentially affected by cannabis use. This study evaluated the interaction of cannabis use and biological sex on cognition, and the association between observed cognitive deficits and features of cannabis use. METHODS: Cognitive measures were assessed in those with regular, ongoing, cannabis use (N = 40; 22 female) and non-using peers (N = 40; 23 female). Intelligence, psychomotor speed, and verbal working memory were measured with the Wechsler Abbreviated Scale of Intelligence, Digit Symbol Test, and Digit Span and Hopkins Verbal Learning Test, respectively. Associations between cognitive measures and cannabis use features (e.g., lifetime cannabis use, age of initiation, time since last use of cannabis, recent high-concentration tetrahydrocannabinoid exposure) were also evaluated. RESULTS: No main effects of group were observed across measures. Significant interactions between group and biological sex were observed on measures of intelligence, psychomotor speed, and verbal learning, with greatest group differences observed between males with and without regular cannabis use. Psychomotor performance was negatively correlated with lifetime cannabis exposure. Female and male cannabis use groups did not differ in features of cannabis use. CONCLUSIONS: Findings suggest that biological sex influences the relationship between cannabis and cognition, with males potentially being more vulnerable to the neurocognitive deficits related to cannabis use. 2021-07 /pmc/articles/PMC8830784/ /pubmed/34261548 http://dx.doi.org/10.1017/S1355617721000606 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Martin, Ashley M. Schnakenberg
D’Souza, Deepak Cyril
Newman, Sharlene D.
Hetrick, William P.
O’Donnell, Brian F.
Differential Cognitive Performance in Females and Males with Regular Cannabis Use
title Differential Cognitive Performance in Females and Males with Regular Cannabis Use
title_full Differential Cognitive Performance in Females and Males with Regular Cannabis Use
title_fullStr Differential Cognitive Performance in Females and Males with Regular Cannabis Use
title_full_unstemmed Differential Cognitive Performance in Females and Males with Regular Cannabis Use
title_short Differential Cognitive Performance in Females and Males with Regular Cannabis Use
title_sort differential cognitive performance in females and males with regular cannabis use
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830784/
https://www.ncbi.nlm.nih.gov/pubmed/34261548
http://dx.doi.org/10.1017/S1355617721000606
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