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Meta-imputation of transcriptome from genotypes across multiple datasets by leveraging publicly available summary-level data
Transcriptome wide association studies (TWAS) can be used as a powerful method to identify and interpret the underlying biological mechanisms behind GWAS by mapping gene expression levels with phenotypes. In TWAS, gene expression is often imputed from individual-level genotypes of regulatory variant...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830793/ https://www.ncbi.nlm.nih.gov/pubmed/35100255 http://dx.doi.org/10.1371/journal.pgen.1009571 |