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Human Gut Microbes Associated with Systolic Blood Pressure
Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831042/ https://www.ncbi.nlm.nih.gov/pubmed/35154822 http://dx.doi.org/10.1155/2022/2923941 |
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author | Joishy, Tulsi Kumari Jha, Aashish Oudah, Mai Das, Santanu Adak, Atanu Deb, Dibyayan Khan, Mojibur Rohman |
author_facet | Joishy, Tulsi Kumari Jha, Aashish Oudah, Mai Das, Santanu Adak, Atanu Deb, Dibyayan Khan, Mojibur Rohman |
author_sort | Joishy, Tulsi Kumari |
collection | PubMed |
description | Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists—remains unknown. Cardiovascular diseases are the leading cause of mortality in India affecting 55 million people, and high blood pressure is one of the primary risk factors for cardiovascular diseases. We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Our analysis reveals a robust link between the gut microbiome diversity and composition and systolic blood pressure. Moreover, several genera previously associated with hypertension in non-Indian populations were also associated with systolic blood pressure in this cohort and these genera were predictors of elevated blood pressure in these populations. These findings confer opportunities to design personalized, preventative, and targeted interventions harnessing the gut microbiome to tackle the burden of cardiovascular diseases in India. |
format | Online Article Text |
id | pubmed-8831042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88310422022-02-11 Human Gut Microbes Associated with Systolic Blood Pressure Joishy, Tulsi Kumari Jha, Aashish Oudah, Mai Das, Santanu Adak, Atanu Deb, Dibyayan Khan, Mojibur Rohman Int J Hypertens Research Article Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists—remains unknown. Cardiovascular diseases are the leading cause of mortality in India affecting 55 million people, and high blood pressure is one of the primary risk factors for cardiovascular diseases. We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Our analysis reveals a robust link between the gut microbiome diversity and composition and systolic blood pressure. Moreover, several genera previously associated with hypertension in non-Indian populations were also associated with systolic blood pressure in this cohort and these genera were predictors of elevated blood pressure in these populations. These findings confer opportunities to design personalized, preventative, and targeted interventions harnessing the gut microbiome to tackle the burden of cardiovascular diseases in India. Hindawi 2022-02-03 /pmc/articles/PMC8831042/ /pubmed/35154822 http://dx.doi.org/10.1155/2022/2923941 Text en Copyright © 2022 Tulsi Kumari Joishy et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Joishy, Tulsi Kumari Jha, Aashish Oudah, Mai Das, Santanu Adak, Atanu Deb, Dibyayan Khan, Mojibur Rohman Human Gut Microbes Associated with Systolic Blood Pressure |
title | Human Gut Microbes Associated with Systolic Blood Pressure |
title_full | Human Gut Microbes Associated with Systolic Blood Pressure |
title_fullStr | Human Gut Microbes Associated with Systolic Blood Pressure |
title_full_unstemmed | Human Gut Microbes Associated with Systolic Blood Pressure |
title_short | Human Gut Microbes Associated with Systolic Blood Pressure |
title_sort | human gut microbes associated with systolic blood pressure |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831042/ https://www.ncbi.nlm.nih.gov/pubmed/35154822 http://dx.doi.org/10.1155/2022/2923941 |
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