Bioavailability and Safety of Dihydroquercetin (Review)

Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as p...

Descripción completa

Detalles Bibliográficos
Autores principales: Orlova, S. V., Tatarinov, V. V., Nikitina, E. A., Sheremeta, A. V., Ivlev, V. A., Vasil’ev, V. G., Paliy, K. V., Goryainov, S. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831168/
https://www.ncbi.nlm.nih.gov/pubmed/35194263
http://dx.doi.org/10.1007/s11094-022-02548-8
Descripción
Sumario:Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability.

Ejemplares similares