Bioavailability and Safety of Dihydroquercetin (Review)

Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as p...

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Autores principales: Orlova, S. V., Tatarinov, V. V., Nikitina, E. A., Sheremeta, A. V., Ivlev, V. A., Vasil’ev, V. G., Paliy, K. V., Goryainov, S. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831168/
https://www.ncbi.nlm.nih.gov/pubmed/35194263
http://dx.doi.org/10.1007/s11094-022-02548-8
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author Orlova, S. V.
Tatarinov, V. V.
Nikitina, E. A.
Sheremeta, A. V.
Ivlev, V. A.
Vasil’ev, V. G.
Paliy, K. V.
Goryainov, S. V.
author_facet Orlova, S. V.
Tatarinov, V. V.
Nikitina, E. A.
Sheremeta, A. V.
Ivlev, V. A.
Vasil’ev, V. G.
Paliy, K. V.
Goryainov, S. V.
author_sort Orlova, S. V.
collection PubMed
description Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability.
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spelling pubmed-88311682022-02-18 Bioavailability and Safety of Dihydroquercetin (Review) Orlova, S. V. Tatarinov, V. V. Nikitina, E. A. Sheremeta, A. V. Ivlev, V. A. Vasil’ev, V. G. Paliy, K. V. Goryainov, S. V. Pharm Chem J Molecular-Biological Problems of Drug Design and Mechanism of Drug Action Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability. Springer US 2022-02-11 2022 /pmc/articles/PMC8831168/ /pubmed/35194263 http://dx.doi.org/10.1007/s11094-022-02548-8 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Orlova, S. V.
Tatarinov, V. V.
Nikitina, E. A.
Sheremeta, A. V.
Ivlev, V. A.
Vasil’ev, V. G.
Paliy, K. V.
Goryainov, S. V.
Bioavailability and Safety of Dihydroquercetin (Review)
title Bioavailability and Safety of Dihydroquercetin (Review)
title_full Bioavailability and Safety of Dihydroquercetin (Review)
title_fullStr Bioavailability and Safety of Dihydroquercetin (Review)
title_full_unstemmed Bioavailability and Safety of Dihydroquercetin (Review)
title_short Bioavailability and Safety of Dihydroquercetin (Review)
title_sort bioavailability and safety of dihydroquercetin (review)
topic Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831168/
https://www.ncbi.nlm.nih.gov/pubmed/35194263
http://dx.doi.org/10.1007/s11094-022-02548-8
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