Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire

Many pathologies can cause gonadotropin-independent precocious puberty (GIPP) in prepubertal boys. Leydig cell tumor is one rare cause of this presentation. Here we present a six-year-old boy with features of isosexual precocious puberty, high testosterone levels, low gonadotropin levels, and bone a...

Descripción completa

Detalles Bibliográficos
Autores principales: Singhania, Pankaj, Bhattacharjee, Rana, Pratim Chakraborty, Partha, Chowdhury, Subhankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831234/
https://www.ncbi.nlm.nih.gov/pubmed/35165615
http://dx.doi.org/10.7759/cureus.21165
_version_ 1784648460951093248
author Singhania, Pankaj
Bhattacharjee, Rana
Pratim Chakraborty, Partha
Chowdhury, Subhankar
author_facet Singhania, Pankaj
Bhattacharjee, Rana
Pratim Chakraborty, Partha
Chowdhury, Subhankar
author_sort Singhania, Pankaj
collection PubMed
description Many pathologies can cause gonadotropin-independent precocious puberty (GIPP) in prepubertal boys. Leydig cell tumor is one rare cause of this presentation. Here we present a six-year-old boy with features of isosexual precocious puberty, high testosterone levels, low gonadotropin levels, and bone age advancement. Testicular USG revealed a left-sided testicular tumor. The left testis was removed surgically, and the Leydig cell tumor was confirmed on histopathology. Post orchiectomy, the boy had elevated testosterone levels with raised luteinizing hormone (LH) levels. A diagnosis of gonadotropin-dependent precocious puberty (GDPP) was made. He has been initiated on monthly gonadotropin-releasing hormone (GnRH) agonist therapy.
format Online
Article
Text
id pubmed-8831234
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-88312342022-02-13 Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire Singhania, Pankaj Bhattacharjee, Rana Pratim Chakraborty, Partha Chowdhury, Subhankar Cureus Endocrinology/Diabetes/Metabolism Many pathologies can cause gonadotropin-independent precocious puberty (GIPP) in prepubertal boys. Leydig cell tumor is one rare cause of this presentation. Here we present a six-year-old boy with features of isosexual precocious puberty, high testosterone levels, low gonadotropin levels, and bone age advancement. Testicular USG revealed a left-sided testicular tumor. The left testis was removed surgically, and the Leydig cell tumor was confirmed on histopathology. Post orchiectomy, the boy had elevated testosterone levels with raised luteinizing hormone (LH) levels. A diagnosis of gonadotropin-dependent precocious puberty (GDPP) was made. He has been initiated on monthly gonadotropin-releasing hormone (GnRH) agonist therapy. Cureus 2022-01-12 /pmc/articles/PMC8831234/ /pubmed/35165615 http://dx.doi.org/10.7759/cureus.21165 Text en Copyright © 2022, Singhania et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Singhania, Pankaj
Bhattacharjee, Rana
Pratim Chakraborty, Partha
Chowdhury, Subhankar
Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire
title Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire
title_full Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire
title_fullStr Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire
title_full_unstemmed Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire
title_short Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire
title_sort leydig cell tumor-induced gonadotropin-independent precocious puberty progressing to gonadotropin-dependent precocious puberty post orchiectomy: out of the frying pan into the fire
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831234/
https://www.ncbi.nlm.nih.gov/pubmed/35165615
http://dx.doi.org/10.7759/cureus.21165
work_keys_str_mv AT singhaniapankaj leydigcelltumorinducedgonadotropinindependentprecociouspubertyprogressingtogonadotropindependentprecociouspubertypostorchiectomyoutofthefryingpanintothefire
AT bhattacharjeerana leydigcelltumorinducedgonadotropinindependentprecociouspubertyprogressingtogonadotropindependentprecociouspubertypostorchiectomyoutofthefryingpanintothefire
AT pratimchakrabortypartha leydigcelltumorinducedgonadotropinindependentprecociouspubertyprogressingtogonadotropindependentprecociouspubertypostorchiectomyoutofthefryingpanintothefire
AT chowdhurysubhankar leydigcelltumorinducedgonadotropinindependentprecociouspubertyprogressingtogonadotropindependentprecociouspubertypostorchiectomyoutofthefryingpanintothefire

Ejemplares similares