Organoid: Next-Generation Modeling of Cancer Research and Drug Development

Colorectal carcinoma is a highly prevalent and heterogeneous gastrointestinal malignancy. The emergence of organoid technology has provided a new direction for colorectal cancer research. As a novel-type model, organoid has significant advantages compared with conventional tumor research models, cha...

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Autores principales: Liu, Jungang, Huang, Xiaoliang, Huang, Lihaoyun, Huang, Jinlian, Liang, Dingyu, Liao, Lixian, Deng, Yuqing, Zhang, Lihua, Zhang, Beibei, Tang, Weizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831330/
https://www.ncbi.nlm.nih.gov/pubmed/35155215
http://dx.doi.org/10.3389/fonc.2021.826613
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author Liu, Jungang
Huang, Xiaoliang
Huang, Lihaoyun
Huang, Jinlian
Liang, Dingyu
Liao, Lixian
Deng, Yuqing
Zhang, Lihua
Zhang, Beibei
Tang, Weizhong
author_facet Liu, Jungang
Huang, Xiaoliang
Huang, Lihaoyun
Huang, Jinlian
Liang, Dingyu
Liao, Lixian
Deng, Yuqing
Zhang, Lihua
Zhang, Beibei
Tang, Weizhong
author_sort Liu, Jungang
collection PubMed
description Colorectal carcinoma is a highly prevalent and heterogeneous gastrointestinal malignancy. The emergence of organoid technology has provided a new direction for colorectal cancer research. As a novel-type model, organoid has significant advantages compared with conventional tumor research models, characterized with the high success rate of construction and the high matching with the original tumor. These characteristics provide new possibilities to study the mechanism of colorectal carcinogenesis and improve the treatment effects. The present literature would mainly summarize the characteristics of tumor organoids and the up-to-date technique development of patient-derived organoids (PDOs) and application in colorectal cancer.
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spelling pubmed-88313302022-02-12 Organoid: Next-Generation Modeling of Cancer Research and Drug Development Liu, Jungang Huang, Xiaoliang Huang, Lihaoyun Huang, Jinlian Liang, Dingyu Liao, Lixian Deng, Yuqing Zhang, Lihua Zhang, Beibei Tang, Weizhong Front Oncol Oncology Colorectal carcinoma is a highly prevalent and heterogeneous gastrointestinal malignancy. The emergence of organoid technology has provided a new direction for colorectal cancer research. As a novel-type model, organoid has significant advantages compared with conventional tumor research models, characterized with the high success rate of construction and the high matching with the original tumor. These characteristics provide new possibilities to study the mechanism of colorectal carcinogenesis and improve the treatment effects. The present literature would mainly summarize the characteristics of tumor organoids and the up-to-date technique development of patient-derived organoids (PDOs) and application in colorectal cancer. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8831330/ /pubmed/35155215 http://dx.doi.org/10.3389/fonc.2021.826613 Text en Copyright © 2022 Liu, Huang, Huang, Huang, Liang, Liao, Deng, Zhang, Zhang and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Jungang
Huang, Xiaoliang
Huang, Lihaoyun
Huang, Jinlian
Liang, Dingyu
Liao, Lixian
Deng, Yuqing
Zhang, Lihua
Zhang, Beibei
Tang, Weizhong
Organoid: Next-Generation Modeling of Cancer Research and Drug Development
title Organoid: Next-Generation Modeling of Cancer Research and Drug Development
title_full Organoid: Next-Generation Modeling of Cancer Research and Drug Development
title_fullStr Organoid: Next-Generation Modeling of Cancer Research and Drug Development
title_full_unstemmed Organoid: Next-Generation Modeling of Cancer Research and Drug Development
title_short Organoid: Next-Generation Modeling of Cancer Research and Drug Development
title_sort organoid: next-generation modeling of cancer research and drug development
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831330/
https://www.ncbi.nlm.nih.gov/pubmed/35155215
http://dx.doi.org/10.3389/fonc.2021.826613
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