In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells

T follicular helper (Tfh) cells provide signals to initiate and maintain the germinal center (GC) reaction and are crucial for the generation of robust, long-lived antibody responses, but how the GC microenvironment affects Tfh cells is not well understood. Here we develop an in vivo T cell-intrinsi...

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Detalles Bibliográficos
Autores principales: Huang, Bonnie, Phelan, James D., Preite, Silvia, Gomez-Rodriguez, Julio, Johansen, Kristoffer H., Shibata, Hirofumi, Shaffer, Arthur L., Xu, Qin, Jeffrey, Brendan, Kirby, Martha, Anderson, Stacie, Yang, Yandan, Gossa, Selamawit, McGavern, Dorian B., Staudt, Louis M., Schwartzberg, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831505/
https://www.ncbi.nlm.nih.gov/pubmed/35145086
http://dx.doi.org/10.1038/s41467-022-28378-6

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