Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B

Small interfering RNA (siRNA) constitutes a promising therapeutic modality supporting the potential functional cure of hepatitis B. A novel ionizable lipidoid nanoparticle (RBP131) and a state-of-the-art lyophilization technology were developed in this study, enabling to deliver siRNA targeting apol...

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Detalles Bibliográficos
Autores principales: Huang, Yuanyu, Zheng, Shuquan, Guo, Zhaoxu, de Mollerat du Jeu, Xavier, Liang, Xing-Jie, Yang, Zhiwei, Zhang, Hong-Yan, Gao, Shan, Liang, Zicai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831581/
https://www.ncbi.nlm.nih.gov/pubmed/35145057
http://dx.doi.org/10.1038/s41392-021-00859-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831581/
https://www.ncbi.nlm.nih.gov/pubmed/35145057
http://dx.doi.org/10.1038/s41392-021-00859-y

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