Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma

Osteolytic lesions (OL) characterize symptomatic multiple myeloma. The mechanisms of how malignant plasma cells (PC) cause OL in one region while others show no signs of bone destruction despite subtotal infiltration remain unknown. We report on a single-cell RNA sequencing (scRNA-seq) study of PC o...

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Detalles Bibliográficos
Autores principales: Merz, Maximilian, Merz, Almuth Maria Anni, Wang, Jie, Wei, Lei, Hu, Qiang, Hutson, Nicholas, Rondeau, Cherie, Celotto, Kimberly, Belal, Ahmed, Alberico, Ronald, Block, AnneMarie W., Mohammadpour, Hemn, Wallace, Paul K., Tario, Joseph, Luce, Jesse, Glenn, Sean T., Singh, Prashant, Herr, Megan M., Hahn, Theresa, Samur, Mehmet, Munshi, Nikhil, Liu, Song, McCarthy, Philip L., Hillengass, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831582/
https://www.ncbi.nlm.nih.gov/pubmed/35145077
http://dx.doi.org/10.1038/s41467-022-28266-z

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