ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells

DNA cytosine deaminase APOBEC3B (A3B) is an endogenous source of mutations in many human cancers, including multiple myeloma. A3B proteins form catalytically inactive high molecular mass (HMM) complexes in nuclei, however, the regulatory mechanisms of A3B deaminase activity in HMM complexes are stil...

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Detalles Bibliográficos
Autores principales: Kazuma, Yasuhiro, Shirakawa, Kotaro, Tashiro, Yusuke, Yamazaki, Hiroyuki, Nomura, Ryosuke, Horisawa, Yoshihito, Takeuchi, Suguru, Stanford, Emani, Konishi, Yoshinobu, Matsui, Hiroyuki, Matsumoto, Tadahiko, Tanabe, Fumiko, Morishita, Ryo, Ito, Shinji, Takaori-Kondo, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831623/
https://www.ncbi.nlm.nih.gov/pubmed/35145187
http://dx.doi.org/10.1038/s41598-022-06226-3

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