Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

When conditions change, unicellular organisms rewire their metabolism to sustain cell maintenance and cellular growth. Such rewiring may be understood as resource re-allocation under cellular constraints. Eukaryal cells contain metabolically active organelles such as mitochondria, competing for cyto...

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Detalles Bibliográficos
Autores principales: Elsemman, Ibrahim E., Rodriguez Prado, Angelica, Grigaitis, Pranas, Garcia Albornoz, Manuel, Harman, Victoria, Holman, Stephen W., van Heerden, Johan, Bruggeman, Frank J., Bisschops, Mark M. M., Sonnenschein, Nikolaus, Hubbard, Simon, Beynon, Rob, Daran-Lapujade, Pascale, Nielsen, Jens, Teusink, Bas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831649/
https://www.ncbi.nlm.nih.gov/pubmed/35145105
http://dx.doi.org/10.1038/s41467-022-28467-6

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