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Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2

It was reported that MGMT(low) gliomas may still be resistant to TMZ, while the mechanisms remain poorly understood. In this study, we demonstrated that rho-associated kinase 2 (ROCK2), a cytoskeleton regulator, was highly expressed in MGMT(low) recurrent gliomas, and its expression strongly correla...

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Detalles Bibliográficos
Autores principales:	Zhang, Xin, Li, Tao, Yang, Mengdi, Du, Qianming, Wang, Rui, Fu, Bin, Tan, Yingying, Cao, Mengran, Chen, Yaxin, Wang, Qing, Hu, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831658/ https://www.ncbi.nlm.nih.gov/pubmed/35145081 http://dx.doi.org/10.1038/s41419-022-04590-6

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