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Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer

Gynecological cancers seriously affect the reproductive system of females; diseases include ovarian tumors, uterine tumors, endometrial cancers, cervical cancers, and vulva and vaginal tumors. At present, the diagnosis methods of gynecological cancer are insufficiently sensitive and specific, leadin...

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Autores principales: Huang, Wanjun, Kong, Fanhua, Li, Ruolan, Chen, Xiang, Wang, Kunpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831694/
https://www.ncbi.nlm.nih.gov/pubmed/35155260
http://dx.doi.org/10.3389/fonc.2022.827956
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author Huang, Wanjun
Kong, Fanhua
Li, Ruolan
Chen, Xiang
Wang, Kunpeng
author_facet Huang, Wanjun
Kong, Fanhua
Li, Ruolan
Chen, Xiang
Wang, Kunpeng
author_sort Huang, Wanjun
collection PubMed
description Gynecological cancers seriously affect the reproductive system of females; diseases include ovarian tumors, uterine tumors, endometrial cancers, cervical cancers, and vulva and vaginal tumors. At present, the diagnosis methods of gynecological cancer are insufficiently sensitive and specific, leading to failure of early disease detection. N(6)-methyladenosine (m(6)A) plays various biological functions in RNA modification and is currently studied extensively. m(6)A modification controls the fate of transcripts and regulates RNA metabolism and biological processes through the interaction of m(6)A methyltransferase (“writer”) and demethylase (“erasers”) and the binding protein decoding m(6)A methylation (“readers”). In the field of epigenetics, m(6)A modification is a dynamic process of reversible regulation of target RNA through its regulatory factors. It plays an important role in many diseases, especially cancer. However, its role in gynecologic cancers has not been fully investigated. Thus, we review the regulatory mechanism, biological functions, and therapeutic prospects of m(6)A RNA methylation regulators in gynecological cancers.
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spelling pubmed-88316942022-02-12 Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer Huang, Wanjun Kong, Fanhua Li, Ruolan Chen, Xiang Wang, Kunpeng Front Oncol Oncology Gynecological cancers seriously affect the reproductive system of females; diseases include ovarian tumors, uterine tumors, endometrial cancers, cervical cancers, and vulva and vaginal tumors. At present, the diagnosis methods of gynecological cancer are insufficiently sensitive and specific, leading to failure of early disease detection. N(6)-methyladenosine (m(6)A) plays various biological functions in RNA modification and is currently studied extensively. m(6)A modification controls the fate of transcripts and regulates RNA metabolism and biological processes through the interaction of m(6)A methyltransferase (“writer”) and demethylase (“erasers”) and the binding protein decoding m(6)A methylation (“readers”). In the field of epigenetics, m(6)A modification is a dynamic process of reversible regulation of target RNA through its regulatory factors. It plays an important role in many diseases, especially cancer. However, its role in gynecologic cancers has not been fully investigated. Thus, we review the regulatory mechanism, biological functions, and therapeutic prospects of m(6)A RNA methylation regulators in gynecological cancers. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8831694/ /pubmed/35155260 http://dx.doi.org/10.3389/fonc.2022.827956 Text en Copyright © 2022 Huang, Kong, Li, Chen and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Huang, Wanjun
Kong, Fanhua
Li, Ruolan
Chen, Xiang
Wang, Kunpeng
Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer
title Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer
title_full Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer
title_fullStr Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer
title_full_unstemmed Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer
title_short Emerging Roles of m(6)A RNA Methylation Regulators in Gynecological Cancer
title_sort emerging roles of m(6)a rna methylation regulators in gynecological cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831694/
https://www.ncbi.nlm.nih.gov/pubmed/35155260
http://dx.doi.org/10.3389/fonc.2022.827956
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