Cargando…

Metnase and EEPD1: DNA Repair Functions and Potential Targets in Cancer Therapy

Cells respond to DNA damage by activating signaling and DNA repair systems, described as the DNA damage response (DDR). Clarifying DDR pathways and their dysregulation in cancer are important for understanding cancer etiology, how cancer cells exploit the DDR to survive endogenous and treatment-rela...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nickoloff, Jac A., Sharma, Neelam, Taylor, Lynn, Allen, Sage J., Lee, Suk-Hee, Hromas, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831698/ https://www.ncbi.nlm.nih.gov/pubmed/35155245 http://dx.doi.org/10.3389/fonc.2022.808757

Ejemplares similares

Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses
por: Sharma, Neelam, et al.
Publicado: (2020)

Metnase/SETMAR: a domesticated primate transposase that enhances DNA repair, replication, and decatenation
por: Shaheen, Montaser, et al.
Publicado: (2010)

The DNA repair component Metnase regulates Chk1 stability
por: Williamson, Elizabeth A, et al.
Publicado: (2014)

Metnase promotes restart and repair of stalled and collapsed replication forks
por: De Haro, Leyma P., et al.
Publicado: (2010)

The Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination
por: Nickoloff, Jac A., et al.
Publicado: (2021)

EEPD1 promotes repair of oxidatively-stressed replication forks
por: Jaiswal, Aruna S, et al.
Publicado: (2023)

The DDN Catalytic Motif Is Required for Metnase Functions in Non-homologous End Joining (NHEJ) Repair and Replication Restart
por: Kim, Hyun-Suk, et al.
Publicado: (2014)

Endonuclease EEPD1 Is a Gatekeeper for Repair of Stressed Replication Forks
por: Kim, Hyun-Suk, et al.
Publicado: (2017)

Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells
por: Wray, Justin, et al.
Publicado: (2009)

Nucleases and Co-Factors in DNA Replication Stress Responses
por: Nickoloff, Jac A., et al.
Publicado: (2022)

The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis
por: Chun, Changzoon, et al.
Publicado: (2016)

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation
por: Williamson, Elizabeth A., et al.
Publicado: (2008)

The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells
por: Hromas, Robert, et al.
Publicado: (2017)

Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition
por: Ponder, Jessica, et al.
Publicado: (2011)

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair
por: Wu, Yuehan, et al.
Publicado: (2015)

Drugging the Cancers Addicted to DNA Repair
por: Nickoloff, Jac A., et al.
Publicado: (2017)

Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy
por: Nickoloff, Jac A., et al.
Publicado: (2021)

The SET Domain Is Essential for Metnase Functions in Replication Restart and the 5’ End of SS-Overhang Cleavage
por: Kim, Hyun-Suk, et al.
Publicado: (2015)

Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy
por: Nickoloff, Jac A., et al.
Publicado: (2020)

Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing
por: Rath, Abhijit, et al.
Publicado: (2014)

Assaying DNA double-strand break induction and repair as fast as a speeding comet
por: Nickoloff, Jac A.
Publicado: (2013)

EEPD1: Breaking and Rescuing the Replication Fork
por: Liu, Yilun
Publicado: (2016)

The roles of the human SETMAR (Metnase) protein in illegitimate DNA recombination and non-homologous end joining repair
por: Tellier, Michael, et al.
Publicado: (2019)

DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E(2) Growth Factor Release in Response to Low and High LET Ionizing Radiation
por: Allen, Christopher P., et al.
Publicado: (2015)

Potential Role for the Metnase Transposase Fusion Gene in Colon Cancer through the Regulation of Key Genes
por: Apostolou, Panagiotis, et al.
Publicado: (2014)

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy
por: Nickoloff, Jac A.
Publicado: (2022)

EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux
por: Nelson, Jessica Kristine, et al.
Publicado: (2017)

Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats
por: Schildkraut, Ezra, et al.
Publicado: (2005)

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
por: Lagunas-Rangel, Francisco Alejandro, et al.
Publicado: (2020)

Targeting DNA Damage Repair for Immune Checkpoint Inhibition: Mechanisms and Potential Clinical Applications
por: Sun, Wei, et al.
Publicado: (2021)

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
por: Biau, Julian, et al.
Publicado: (2019)

Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy
por: Dungl, Daniela A., et al.
Publicado: (2015)

DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy
por: Mladenov, Emil, et al.
Publicado: (2013)

BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage
por: Lu, Huimei, et al.
Publicado: (2007)

Targeting ATM-deficient CLL through interference with DNA repair pathways
por: Knittel, Gero, et al.
Publicado: (2015)

DNA repair mechanisms in cancer development and therapy
por: Torgovnick, Alessandro, et al.
Publicado: (2015)

The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer
por: Burgess, Joshua T., et al.
Publicado: (2020)

Identification of DNA repair gene signature and potential molecular subtypes in hepatocellular carcinoma
por: Bai, Yi, et al.
Publicado: (2023)

Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases
por: Turchi, John J., et al.
Publicado: (2022)

Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors
por: Greenberger, Joel S., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jjbr5mfqbdgos0g56gbmv7g622