The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease

The N6-methyladenosine (m6A) modification is the most abundant internal modification of messenger RNA (mRNA) in higher eukaryotes. Under the actions of methyltransferase, demethylase and methyl-binding protein, m6A resulting from RNA methylation becomes dynamic and reversible, similar to that from D...

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Autores principales: Cai, Teng, Atteh, Lawrence Lawer, Zhang, Xianzhuo, Huang, Chongfei, Bai, Mingzhen, Ma, Haidong, Zhang, Chao, Fu, Wenkang, Gao, Long, Lin, Yanyan, Meng, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831730/
https://www.ncbi.nlm.nih.gov/pubmed/35155557
http://dx.doi.org/10.3389/fsurg.2022.819335
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author Cai, Teng
Atteh, Lawrence Lawer
Zhang, Xianzhuo
Huang, Chongfei
Bai, Mingzhen
Ma, Haidong
Zhang, Chao
Fu, Wenkang
Gao, Long
Lin, Yanyan
Meng, Wenbo
author_facet Cai, Teng
Atteh, Lawrence Lawer
Zhang, Xianzhuo
Huang, Chongfei
Bai, Mingzhen
Ma, Haidong
Zhang, Chao
Fu, Wenkang
Gao, Long
Lin, Yanyan
Meng, Wenbo
author_sort Cai, Teng
collection PubMed
description The N6-methyladenosine (m6A) modification is the most abundant internal modification of messenger RNA (mRNA) in higher eukaryotes. Under the actions of methyltransferase, demethylase and methyl-binding protein, m6A resulting from RNA methylation becomes dynamic and reversible, similar to that from DNA methylation, and this effect allows the generated mRNA to participate in metabolism processes, such as splicing, transport, translation, and degradation. The most common tumors are those found in the gastrointestinal tract, and research on these tumors has flourished since the discovery of m6A. Overall, further analysis of the mechanism of m6A and its role in tumors may contribute to new ideas for the treatment of tumors. m6A also plays an important role in non-tumor diseases of the gastrointestinal tract. This manuscript reviews the current knowledge of m6A-related proteins, mRNA metabolism and their application in gastrointestinal tract disease.
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spelling pubmed-88317302022-02-12 The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease Cai, Teng Atteh, Lawrence Lawer Zhang, Xianzhuo Huang, Chongfei Bai, Mingzhen Ma, Haidong Zhang, Chao Fu, Wenkang Gao, Long Lin, Yanyan Meng, Wenbo Front Surg Surgery The N6-methyladenosine (m6A) modification is the most abundant internal modification of messenger RNA (mRNA) in higher eukaryotes. Under the actions of methyltransferase, demethylase and methyl-binding protein, m6A resulting from RNA methylation becomes dynamic and reversible, similar to that from DNA methylation, and this effect allows the generated mRNA to participate in metabolism processes, such as splicing, transport, translation, and degradation. The most common tumors are those found in the gastrointestinal tract, and research on these tumors has flourished since the discovery of m6A. Overall, further analysis of the mechanism of m6A and its role in tumors may contribute to new ideas for the treatment of tumors. m6A also plays an important role in non-tumor diseases of the gastrointestinal tract. This manuscript reviews the current knowledge of m6A-related proteins, mRNA metabolism and their application in gastrointestinal tract disease. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8831730/ /pubmed/35155557 http://dx.doi.org/10.3389/fsurg.2022.819335 Text en Copyright © 2022 Cai, Atteh, Zhang, Huang, Bai, Ma, Zhang, Fu, Gao, Lin and Meng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Cai, Teng
Atteh, Lawrence Lawer
Zhang, Xianzhuo
Huang, Chongfei
Bai, Mingzhen
Ma, Haidong
Zhang, Chao
Fu, Wenkang
Gao, Long
Lin, Yanyan
Meng, Wenbo
The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease
title The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease
title_full The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease
title_fullStr The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease
title_full_unstemmed The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease
title_short The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease
title_sort n6-methyladenosine modification and its role in mrna metabolism and gastrointestinal tract disease
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831730/
https://www.ncbi.nlm.nih.gov/pubmed/35155557
http://dx.doi.org/10.3389/fsurg.2022.819335
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