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Interleukin-1β More Than Mechanical Loading Induces a Degenerative Phenotype in Human Annulus Fibrosus Cells, Partially Impaired by Anti-Proteolytic Activity of Mesenchymal Stem Cell Secretome

Mesenchymal stem/stromal cell (MSC)–based therapies for low back pain and intervertebral disc (IVD) degeneration have been emerging, despite the poor knowledge of their full mechanism of action. As failure of the annulus fibrosus (AF) is often associated with IVD herniation and inflammation, the obj...

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Detalles Bibliográficos
Autores principales:	Gonçalves, Raquel M., Saggese, Taryn, Yong, Zhiyao, Ferreira, Joana R., Ignatius, Anita, Wilke, Hans-Joachim, Neidlinger-Wilke, Cornelia, Teixeira, Graciosa Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831733/ https://www.ncbi.nlm.nih.gov/pubmed/35155408 http://dx.doi.org/10.3389/fbioe.2021.802789

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