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T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas

Survival outcomes for patients with lower grade gliomas (LrGG) continue to improve. However, damage caused both by tumor growth and by the consequences of treatment often leads to significantly impaired cognitive function and quality of life (QoL). While neuropsychological testing is not routine, se...

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Autores principales: Luks, Tracy L., Villanueva-Meyer, Javier E., Weyer-Jamora, Christina, Gehring, Karin, Jakary, Angela, Hervey-Jumper, Shawn L., Braunstein, Steve E., Bracci, Paige M., Brie, Melissa S., Smith, Ellen M., Chang, Susan M., Taylor, Jennie W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831734/
https://www.ncbi.nlm.nih.gov/pubmed/35153976
http://dx.doi.org/10.3389/fneur.2021.769345
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author Luks, Tracy L.
Villanueva-Meyer, Javier E.
Weyer-Jamora, Christina
Gehring, Karin
Jakary, Angela
Hervey-Jumper, Shawn L.
Braunstein, Steve E.
Bracci, Paige M.
Brie, Melissa S.
Smith, Ellen M.
Chang, Susan M.
Taylor, Jennie W.
author_facet Luks, Tracy L.
Villanueva-Meyer, Javier E.
Weyer-Jamora, Christina
Gehring, Karin
Jakary, Angela
Hervey-Jumper, Shawn L.
Braunstein, Steve E.
Bracci, Paige M.
Brie, Melissa S.
Smith, Ellen M.
Chang, Susan M.
Taylor, Jennie W.
author_sort Luks, Tracy L.
collection PubMed
description Survival outcomes for patients with lower grade gliomas (LrGG) continue to improve. However, damage caused both by tumor growth and by the consequences of treatment often leads to significantly impaired cognitive function and quality of life (QoL). While neuropsychological testing is not routine, serial clinical MRIs are standard of care for patients with LrGG. Thus, having a greater understanding of MRI indicators of cognitive and QoL impairment risk could be beneficial to patients and clinicians. In this work we sought to test the hypothesis that in clinically stable LrGG patients, T2 FLAIR hyperintensity volumes at the time of cognitive assessment are associated with impairments of cognitive function and QoL and could be used to help identify patients for cognitive and QoL assessments and interventions. We performed anatomical MR imaging, cognitive testing and QoL assessments cross-sectionally in 30 clinically stable grade 2 and 3 glioma patients with subjective cognitive concerns who were 6 or more months post-treatment. Larger post-surgical T2 FLAIR volume at testing was significantly associated with lower cognitive performance, while pre-surgical tumor volume was not. Older patients had lower cognitive performance than younger patients, even after accounting for normal age-related declines in performance. Patients with Astrocytoma, IDH mutant LrGGs were more likely to show lower cognitive performance than patients with Oligodendroglioma, IDH mutant 1p19q co-deleted LrGGs. Previous treatment with combined radiation and chemotherapy was associated with poorer self-reported QoL, including self-reported cognitive function. This study demonstrates the importance of appreciating that LrGG patients may experience impairments in cognitive function and QoL over their disease course, including during periods of otherwise sustained clinical stability. Imaging factors can be helpful in identifying vulnerable patients who would benefit from cognitive assessment and rehabilitation.
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spelling pubmed-88317342022-02-12 T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas Luks, Tracy L. Villanueva-Meyer, Javier E. Weyer-Jamora, Christina Gehring, Karin Jakary, Angela Hervey-Jumper, Shawn L. Braunstein, Steve E. Bracci, Paige M. Brie, Melissa S. Smith, Ellen M. Chang, Susan M. Taylor, Jennie W. Front Neurol Neurology Survival outcomes for patients with lower grade gliomas (LrGG) continue to improve. However, damage caused both by tumor growth and by the consequences of treatment often leads to significantly impaired cognitive function and quality of life (QoL). While neuropsychological testing is not routine, serial clinical MRIs are standard of care for patients with LrGG. Thus, having a greater understanding of MRI indicators of cognitive and QoL impairment risk could be beneficial to patients and clinicians. In this work we sought to test the hypothesis that in clinically stable LrGG patients, T2 FLAIR hyperintensity volumes at the time of cognitive assessment are associated with impairments of cognitive function and QoL and could be used to help identify patients for cognitive and QoL assessments and interventions. We performed anatomical MR imaging, cognitive testing and QoL assessments cross-sectionally in 30 clinically stable grade 2 and 3 glioma patients with subjective cognitive concerns who were 6 or more months post-treatment. Larger post-surgical T2 FLAIR volume at testing was significantly associated with lower cognitive performance, while pre-surgical tumor volume was not. Older patients had lower cognitive performance than younger patients, even after accounting for normal age-related declines in performance. Patients with Astrocytoma, IDH mutant LrGGs were more likely to show lower cognitive performance than patients with Oligodendroglioma, IDH mutant 1p19q co-deleted LrGGs. Previous treatment with combined radiation and chemotherapy was associated with poorer self-reported QoL, including self-reported cognitive function. This study demonstrates the importance of appreciating that LrGG patients may experience impairments in cognitive function and QoL over their disease course, including during periods of otherwise sustained clinical stability. Imaging factors can be helpful in identifying vulnerable patients who would benefit from cognitive assessment and rehabilitation. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8831734/ /pubmed/35153976 http://dx.doi.org/10.3389/fneur.2021.769345 Text en Copyright © 2022 Luks, Villanueva-Meyer, Weyer-Jamora, Gehring, Jakary, Hervey-Jumper, Braunstein, Bracci, Brie, Smith, Chang and Taylor. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Luks, Tracy L.
Villanueva-Meyer, Javier E.
Weyer-Jamora, Christina
Gehring, Karin
Jakary, Angela
Hervey-Jumper, Shawn L.
Braunstein, Steve E.
Bracci, Paige M.
Brie, Melissa S.
Smith, Ellen M.
Chang, Susan M.
Taylor, Jennie W.
T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas
title T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas
title_full T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas
title_fullStr T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas
title_full_unstemmed T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas
title_short T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas
title_sort t2 flair hyperintensity volume is associated with cognitive function and quality of life in clinically stable patients with lower grade gliomas
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831734/
https://www.ncbi.nlm.nih.gov/pubmed/35153976
http://dx.doi.org/10.3389/fneur.2021.769345
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