Cargando…

Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model

Microvascular and Macrovascular diseases are serious complications of diabetic mellitus, which significantly affect the life quality of diabetic patients. Quantitative description of the relationship between temperature and blood flow is considerably important for non-invasive detection of blood ves...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yue-Ping, Cheng, Rui-Hao, He, Ying, Mu, Li-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831761/
https://www.ncbi.nlm.nih.gov/pubmed/35155402
http://dx.doi.org/10.3389/fbioe.2021.786615
_version_ 1784648574032674816
author Wang, Yue-Ping
Cheng, Rui-Hao
He, Ying
Mu, Li-Zhong
author_facet Wang, Yue-Ping
Cheng, Rui-Hao
He, Ying
Mu, Li-Zhong
author_sort Wang, Yue-Ping
collection PubMed
description Microvascular and Macrovascular diseases are serious complications of diabetic mellitus, which significantly affect the life quality of diabetic patients. Quantitative description of the relationship between temperature and blood flow is considerably important for non-invasive detection of blood vessel structural and functional lesions. In this study, thermal analysis has been employed to predict blood flow alterations in a foot and a cubic skin model successively by using a discrete vessel-porous media model and further compared the blood flows in 31 diabetic patients. The tissue is regarded as porous media whose liquid phase represents the blood flow in capillaries and solid phase refers to the tissue part. Discrete vascular segments composed of arteries, arterioles, veins, and venules were embedded in the foot model. In the foot thermal analysis, the temperature distributions with different inlet vascular stenosis were simulated. The local temperature area sensitive to the reduction of perfusion was obtained under different inlet blood flow conditions. The discrete vascular-porous media model was further applied in the assessment of the skin blood flow by coupling the measured skin temperatures of diabetic patients and an inverse method. In comparison with the estimated blood flows among the diabetic patients, delayed blood flow regulation was found in some of diabetic patients, implying that there may be some vascular disorders in these patients. The conclusion confirms the one in our previous experiment on diabetic rats. Most of the patients predicted to be with vascular disorders were diagnosed as vascular complication in clinical settings as well, suggesting the potential applications of the vascular-porous media model in health management of diabetic patients.
format Online
Article
Text
id pubmed-8831761
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88317612022-02-12 Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model Wang, Yue-Ping Cheng, Rui-Hao He, Ying Mu, Li-Zhong Front Bioeng Biotechnol Bioengineering and Biotechnology Microvascular and Macrovascular diseases are serious complications of diabetic mellitus, which significantly affect the life quality of diabetic patients. Quantitative description of the relationship between temperature and blood flow is considerably important for non-invasive detection of blood vessel structural and functional lesions. In this study, thermal analysis has been employed to predict blood flow alterations in a foot and a cubic skin model successively by using a discrete vessel-porous media model and further compared the blood flows in 31 diabetic patients. The tissue is regarded as porous media whose liquid phase represents the blood flow in capillaries and solid phase refers to the tissue part. Discrete vascular segments composed of arteries, arterioles, veins, and venules were embedded in the foot model. In the foot thermal analysis, the temperature distributions with different inlet vascular stenosis were simulated. The local temperature area sensitive to the reduction of perfusion was obtained under different inlet blood flow conditions. The discrete vascular-porous media model was further applied in the assessment of the skin blood flow by coupling the measured skin temperatures of diabetic patients and an inverse method. In comparison with the estimated blood flows among the diabetic patients, delayed blood flow regulation was found in some of diabetic patients, implying that there may be some vascular disorders in these patients. The conclusion confirms the one in our previous experiment on diabetic rats. Most of the patients predicted to be with vascular disorders were diagnosed as vascular complication in clinical settings as well, suggesting the potential applications of the vascular-porous media model in health management of diabetic patients. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8831761/ /pubmed/35155402 http://dx.doi.org/10.3389/fbioe.2021.786615 Text en Copyright © 2022 Wang, Cheng, He and Mu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Yue-Ping
Cheng, Rui-Hao
He, Ying
Mu, Li-Zhong
Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model
title Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model
title_full Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model
title_fullStr Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model
title_full_unstemmed Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model
title_short Thermal Analysis of Blood Flow Alterations in Human Hand and Foot Based on Vascular-Porous Media Model
title_sort thermal analysis of blood flow alterations in human hand and foot based on vascular-porous media model
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831761/
https://www.ncbi.nlm.nih.gov/pubmed/35155402
http://dx.doi.org/10.3389/fbioe.2021.786615
work_keys_str_mv AT wangyueping thermalanalysisofbloodflowalterationsinhumanhandandfootbasedonvascularporousmediamodel
AT chengruihao thermalanalysisofbloodflowalterationsinhumanhandandfootbasedonvascularporousmediamodel
AT heying thermalanalysisofbloodflowalterationsinhumanhandandfootbasedonvascularporousmediamodel
AT mulizhong thermalanalysisofbloodflowalterationsinhumanhandandfootbasedonvascularporousmediamodel