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Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosity

BACKGROUND/AIMS: Thiopurines are key drugs for inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Recently, NUDT15 polymorphism (R139C, c.415C > T) has been shown to be associated with thiopurine-induced adverse events in Asian populations. In patients w...

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Detalles Bibliográficos
Autores principales:	Maeda, Takato, Sakuraba, Hirotake, Hiraga, Hiroto, Yoshida, Shukuko, Kakuta, Yoichi, Kikuchi, Hidezumi, Kawaguchi, Shogo, Hasui, Keisuke, Tatsuta, Tetsuya, Chinda, Daisuke, Mikami, Tatsuya, Fukuda, Shinsaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Association for the Study of Intestinal Diseases 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831774/ https://www.ncbi.nlm.nih.gov/pubmed/33472343 http://dx.doi.org/10.5217/ir.2020.00133

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