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Calpain Inhibitor Calpeptin Alleviates Ischemia/Reperfusion-Induced Acute Kidney Injury via Suppressing AIM2 Inflammasome and Upregulating Klotho Protein

Renal ischemia/reperfusion injury is a major contributor of acute kidney injury (AKI), leading to renal cell necrosis, apoptosis, and inflammation. Calpains, a family of Ca(2+)-dependent cysteine proteases, play a pivotal role in the pathogenesis of renal diseases. Several studies have reported calp...

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Detalles Bibliográficos
Autores principales:	Wu, Yong, Yang, Huan, Cheng, Ming, Shi, Jialin, Zhang, Weichen, Liu, Shaojun, Zhang, Minmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831790/ https://www.ncbi.nlm.nih.gov/pubmed/35155498 http://dx.doi.org/10.3389/fmed.2022.811980

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