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Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials
Mitochondrial damage is a critical contributor to stroke‐induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke. Mitochondria quality control promotes neuronal sur...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831937/ https://www.ncbi.nlm.nih.gov/pubmed/35040556 http://dx.doi.org/10.1111/jcmm.17189 |
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author | Tian, Heyan Chen, Xiangyu Liao, Jun Yang, Tong Cheng, Shaowu Mei, Zhigang Ge, Jinwen |
author_facet | Tian, Heyan Chen, Xiangyu Liao, Jun Yang, Tong Cheng, Shaowu Mei, Zhigang Ge, Jinwen |
author_sort | Tian, Heyan |
collection | PubMed |
description | Mitochondrial damage is a critical contributor to stroke‐induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke. Mitochondria quality control promotes neuronal survival via various adaptive responses for preserving mitochondria structure, morphology, quantity and function. The processes of mitochondrial fission and fusion allow for damaged mitochondria to be segregated and facilitate the equilibration of mitochondrial components such as DNA, proteins and metabolites. The process of mitophagy is responsible for the degradation and recycling of damaged mitochondria. This review aims to offer a synopsis of the molecular mechanisms involved in MQC for recapitulating our current understanding of the complex role that MQC plays in the progression of stroke. Speculating on the prospect that targeted manipulation of MQC mechanisms may be exploited for the rationale design of novel therapeutic interventions in the ischaemic stroke and haemorrhagic stroke. In the review, we highlight the potential of MQC as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies. |
format | Online Article Text |
id | pubmed-8831937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88319372022-02-14 Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials Tian, Heyan Chen, Xiangyu Liao, Jun Yang, Tong Cheng, Shaowu Mei, Zhigang Ge, Jinwen J Cell Mol Med Reviews Mitochondrial damage is a critical contributor to stroke‐induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke. Mitochondria quality control promotes neuronal survival via various adaptive responses for preserving mitochondria structure, morphology, quantity and function. The processes of mitochondrial fission and fusion allow for damaged mitochondria to be segregated and facilitate the equilibration of mitochondrial components such as DNA, proteins and metabolites. The process of mitophagy is responsible for the degradation and recycling of damaged mitochondria. This review aims to offer a synopsis of the molecular mechanisms involved in MQC for recapitulating our current understanding of the complex role that MQC plays in the progression of stroke. Speculating on the prospect that targeted manipulation of MQC mechanisms may be exploited for the rationale design of novel therapeutic interventions in the ischaemic stroke and haemorrhagic stroke. In the review, we highlight the potential of MQC as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies. John Wiley and Sons Inc. 2022-01-17 2022-02 /pmc/articles/PMC8831937/ /pubmed/35040556 http://dx.doi.org/10.1111/jcmm.17189 Text en © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Tian, Heyan Chen, Xiangyu Liao, Jun Yang, Tong Cheng, Shaowu Mei, Zhigang Ge, Jinwen Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials |
title | Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials |
title_full | Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials |
title_fullStr | Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials |
title_full_unstemmed | Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials |
title_short | Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials |
title_sort | mitochondrial quality control in stroke: from the mechanisms to therapeutic potentials |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831937/ https://www.ncbi.nlm.nih.gov/pubmed/35040556 http://dx.doi.org/10.1111/jcmm.17189 |
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