Single‐cell RNA‐seq reveals altered NK cell subsets and reduced levels of cytotoxic molecules in patients with ankylosing spondylitis

Ankylosing spondylitis (AS) is an autoimmune disease with unknown aetiology. To unravel the mechanisms mediating AS pathogenesis, we profiled peripheral blood mononuclear cells (PBMCs) from AS patients and healthy subjects using 10X single‐cell RNA sequencing. The frequencies of immune cell subsets...

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Detalles Bibliográficos
Autores principales: Ren, Conglin, Li, Mingshuang, Zheng, Yang, Cai, Bingbing, Du, Weibin, Zhang, Helou, Wu, Fengqing, Tong, Mengsha, Lin, Fu, Wang, Jinfu, Quan, Renfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831943/
https://www.ncbi.nlm.nih.gov/pubmed/34994057
http://dx.doi.org/10.1111/jcmm.17159

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