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Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study
BACKGROUND: Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardiovascular metabolism. However, the causal relationship of thyroid function and cardiometabolic health remains partly unknown. METHODS: The Mendelian randomization (MR) was used to test ge...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832047/ https://www.ncbi.nlm.nih.gov/pubmed/35233224 http://dx.doi.org/10.11909/j.issn.1671-5411.2022.01.004 |
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author | WANG, Jing-Jia ZHUANG, Zhen-Huang YU, Can-Qing WANG, Wen-Yao WANG, Wen-Xiu ZHANG, Kuo MENG, Xiang-Bin GAO, Jun TIAN, Jian ZHENG, Ji-Lin YANG, Jie HUANG, Tao SHAO, Chun-Li TANG, Yi-Da |
author_facet | WANG, Jing-Jia ZHUANG, Zhen-Huang YU, Can-Qing WANG, Wen-Yao WANG, Wen-Xiu ZHANG, Kuo MENG, Xiang-Bin GAO, Jun TIAN, Jian ZHENG, Ji-Lin YANG, Jie HUANG, Tao SHAO, Chun-Li TANG, Yi-Da |
author_sort | WANG, Jing-Jia |
collection | PubMed |
description | BACKGROUND: Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardiovascular metabolism. However, the causal relationship of thyroid function and cardiometabolic health remains partly unknown. METHODS: The Mendelian randomization (MR) was used to test genetic, potentially causal relationships between instrumental variables and cardiometabolic traits. Genetic variants of free thyroxine (FT4) and thyrotropin (TSH) levels within the reference range were used as instrumental variables. Data for genetic associations with cardiometabolic diseases were acquired from the genome-wide association studies of the FinnGen, CARDIoGRAM and CARDIoGRAMplusC4D, CHARGE, and MEGASTROKE. This study was conducted using summary statistic data from large, previously described cohorts. Association between thyroid function and essential hypertension (EHTN), secondary hypertension (SHTN), hyperlipidemia (HPL), type 2 diabetes mellitus (T2DM), ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), pulmonary heart disease (PHD), stroke, and non-rheumatic valve disease (NRVD) were examined. RESULTS: Genetically predicted FT4 levels were associated with SHTN (odds ratio = 0.48; 95% CI = 0.04−0.82,P = 0.027), HPL (odds ratio = 0.67; 95% CI = 0.18−0.88,P = 0.023), T2DM (odds ratio = 0.80; 95% CI = 0.42−0.86,P = 0.005), IHD (odds ratio = 0.85; 95% CI = 0.49−0.98,P = 0.039), NRVD (odds ratio = 0.75; 95% CI = 0.27−0.97,P = 0.039). Additionally, genetically predicted TSH levels were associated with HF (odds ratio = 0.82; 95% CI = 0.68−0.99,P = 0.042), PHD (odds ratio = 0.75; 95% CI = 0.32−0.82,P = 0.006), stroke (odds ratio = 0.95; 95% CI = 0.81−0.97,P = 0.007). However, genetically predicted thyroid function traits were not associated with EHTN and MI. CONCLUSIONS: Our study suggests FT4 and TSH are associated with cardiometabolic diseases, underscoring the importance of the pituitary-thyroid-cardiac axis in cardiometabolic health susceptibility. |
format | Online Article Text |
id | pubmed-8832047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88320472022-02-28 Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study WANG, Jing-Jia ZHUANG, Zhen-Huang YU, Can-Qing WANG, Wen-Yao WANG, Wen-Xiu ZHANG, Kuo MENG, Xiang-Bin GAO, Jun TIAN, Jian ZHENG, Ji-Lin YANG, Jie HUANG, Tao SHAO, Chun-Li TANG, Yi-Da J Geriatr Cardiol Research Article BACKGROUND: Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardiovascular metabolism. However, the causal relationship of thyroid function and cardiometabolic health remains partly unknown. METHODS: The Mendelian randomization (MR) was used to test genetic, potentially causal relationships between instrumental variables and cardiometabolic traits. Genetic variants of free thyroxine (FT4) and thyrotropin (TSH) levels within the reference range were used as instrumental variables. Data for genetic associations with cardiometabolic diseases were acquired from the genome-wide association studies of the FinnGen, CARDIoGRAM and CARDIoGRAMplusC4D, CHARGE, and MEGASTROKE. This study was conducted using summary statistic data from large, previously described cohorts. Association between thyroid function and essential hypertension (EHTN), secondary hypertension (SHTN), hyperlipidemia (HPL), type 2 diabetes mellitus (T2DM), ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), pulmonary heart disease (PHD), stroke, and non-rheumatic valve disease (NRVD) were examined. RESULTS: Genetically predicted FT4 levels were associated with SHTN (odds ratio = 0.48; 95% CI = 0.04−0.82,P = 0.027), HPL (odds ratio = 0.67; 95% CI = 0.18−0.88,P = 0.023), T2DM (odds ratio = 0.80; 95% CI = 0.42−0.86,P = 0.005), IHD (odds ratio = 0.85; 95% CI = 0.49−0.98,P = 0.039), NRVD (odds ratio = 0.75; 95% CI = 0.27−0.97,P = 0.039). Additionally, genetically predicted TSH levels were associated with HF (odds ratio = 0.82; 95% CI = 0.68−0.99,P = 0.042), PHD (odds ratio = 0.75; 95% CI = 0.32−0.82,P = 0.006), stroke (odds ratio = 0.95; 95% CI = 0.81−0.97,P = 0.007). However, genetically predicted thyroid function traits were not associated with EHTN and MI. CONCLUSIONS: Our study suggests FT4 and TSH are associated with cardiometabolic diseases, underscoring the importance of the pituitary-thyroid-cardiac axis in cardiometabolic health susceptibility. Science Press 2022-01-28 /pmc/articles/PMC8832047/ /pubmed/35233224 http://dx.doi.org/10.11909/j.issn.1671-5411.2022.01.004 Text en Copyright and License information: Journal of Geriatric Cardiology 2022 https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Research Article WANG, Jing-Jia ZHUANG, Zhen-Huang YU, Can-Qing WANG, Wen-Yao WANG, Wen-Xiu ZHANG, Kuo MENG, Xiang-Bin GAO, Jun TIAN, Jian ZHENG, Ji-Lin YANG, Jie HUANG, Tao SHAO, Chun-Li TANG, Yi-Da Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study |
title | Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study |
title_full | Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study |
title_fullStr | Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study |
title_full_unstemmed | Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study |
title_short | Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study |
title_sort | assessment of causal direction between thyroid function and cardiometabolic health: a mendelian randomization study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832047/ https://www.ncbi.nlm.nih.gov/pubmed/35233224 http://dx.doi.org/10.11909/j.issn.1671-5411.2022.01.004 |
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