Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism

Sunitinib is a tyrosine kinase inhibitor that is frequently used in the treatment of metastatic renal cell carcinoma (mRCC). As a multikinase inhibitor, numerous off-target side effects of this medication are widely recognized. More recently, endocrine side effects, including hypoadrenalism, are bec...

Descripción completa

Detalles Bibliográficos
Autores principales: Javaid, Anadil, Mathai, Jared, Song, David, Brown, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832234/
https://www.ncbi.nlm.nih.gov/pubmed/35221962
http://dx.doi.org/10.1159/000521206
_version_ 1784648678964723712
author Javaid, Anadil
Mathai, Jared
Song, David
Brown, Stephen
author_facet Javaid, Anadil
Mathai, Jared
Song, David
Brown, Stephen
author_sort Javaid, Anadil
collection PubMed
description Sunitinib is a tyrosine kinase inhibitor that is frequently used in the treatment of metastatic renal cell carcinoma (mRCC). As a multikinase inhibitor, numerous off-target side effects of this medication are widely recognized. More recently, endocrine side effects, including hypoadrenalism, are becoming more apparent. We report a case in which a 71-year-old female experienced recurrent adrenal crises when managed with sunitinib for mRCC on a background of immune-related hypopituitarism and hypoadrenalism as a result of previous treatment with immunotherapy. Clinicians should be aware of this potential toxicity when using such medications and consider further investigation in the appropriate clinical setting.
format Online
Article
Text
id pubmed-8832234
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-88322342022-02-25 Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism Javaid, Anadil Mathai, Jared Song, David Brown, Stephen Case Rep Oncol Case Report Sunitinib is a tyrosine kinase inhibitor that is frequently used in the treatment of metastatic renal cell carcinoma (mRCC). As a multikinase inhibitor, numerous off-target side effects of this medication are widely recognized. More recently, endocrine side effects, including hypoadrenalism, are becoming more apparent. We report a case in which a 71-year-old female experienced recurrent adrenal crises when managed with sunitinib for mRCC on a background of immune-related hypopituitarism and hypoadrenalism as a result of previous treatment with immunotherapy. Clinicians should be aware of this potential toxicity when using such medications and consider further investigation in the appropriate clinical setting. S. Karger AG 2022-01-06 /pmc/articles/PMC8832234/ /pubmed/35221962 http://dx.doi.org/10.1159/000521206 Text en Copyright © 2022 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Javaid, Anadil
Mathai, Jared
Song, David
Brown, Stephen
Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
title Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
title_full Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
title_fullStr Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
title_full_unstemmed Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
title_short Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
title_sort sunitinib-induced adrenal crisis in a patient with pre-existing immunotherapy-related hypopituitarism
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832234/
https://www.ncbi.nlm.nih.gov/pubmed/35221962
http://dx.doi.org/10.1159/000521206
work_keys_str_mv AT javaidanadil sunitinibinducedadrenalcrisisinapatientwithpreexistingimmunotherapyrelatedhypopituitarism
AT mathaijared sunitinibinducedadrenalcrisisinapatientwithpreexistingimmunotherapyrelatedhypopituitarism
AT songdavid sunitinibinducedadrenalcrisisinapatientwithpreexistingimmunotherapyrelatedhypopituitarism
AT brownstephen sunitinibinducedadrenalcrisisinapatientwithpreexistingimmunotherapyrelatedhypopituitarism

Ejemplares similares