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Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives

[Image: see text] In the present study, we report the photochemical transformation of pyrazolo[1,2-a]pyrazolone substrates that reach an excited state upon irradiation with visible light to initiate the homolytic C–N bond cleavage process that yields the corresponding N1-substituted pyrazoles. Moreo...

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Autores principales: Petek, Nejc, Brodnik, Helena, Grošelj, Uroš, Svete, Jurij, Požgan, Franc, Štefane, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832495/
https://www.ncbi.nlm.nih.gov/pubmed/34077227
http://dx.doi.org/10.1021/acs.orglett.1c01376
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author Petek, Nejc
Brodnik, Helena
Grošelj, Uroš
Svete, Jurij
Požgan, Franc
Štefane, Bogdan
author_facet Petek, Nejc
Brodnik, Helena
Grošelj, Uroš
Svete, Jurij
Požgan, Franc
Štefane, Bogdan
author_sort Petek, Nejc
collection PubMed
description [Image: see text] In the present study, we report the photochemical transformation of pyrazolo[1,2-a]pyrazolone substrates that reach an excited state upon irradiation with visible light to initiate the homolytic C–N bond cleavage process that yields the corresponding N1-substituted pyrazoles. Moreover, chemoselective heterolytic C–N bond cleavage is possible in the pyrazolo[1,2-a]pyrazole core in the presence of bromomalonate.
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spelling pubmed-88324952022-02-11 Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives Petek, Nejc Brodnik, Helena Grošelj, Uroš Svete, Jurij Požgan, Franc Štefane, Bogdan Org Lett [Image: see text] In the present study, we report the photochemical transformation of pyrazolo[1,2-a]pyrazolone substrates that reach an excited state upon irradiation with visible light to initiate the homolytic C–N bond cleavage process that yields the corresponding N1-substituted pyrazoles. Moreover, chemoselective heterolytic C–N bond cleavage is possible in the pyrazolo[1,2-a]pyrazole core in the presence of bromomalonate. American Chemical Society 2021-06-02 2021-07-16 /pmc/articles/PMC8832495/ /pubmed/34077227 http://dx.doi.org/10.1021/acs.orglett.1c01376 Text en © 2021 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Petek, Nejc
Brodnik, Helena
Grošelj, Uroš
Svete, Jurij
Požgan, Franc
Štefane, Bogdan
Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives
title Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives
title_full Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives
title_fullStr Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives
title_full_unstemmed Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives
title_short Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives
title_sort visible-light driven selective c–n bond scission in anti-bimane-like derivatives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832495/
https://www.ncbi.nlm.nih.gov/pubmed/34077227
http://dx.doi.org/10.1021/acs.orglett.1c01376
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