Cargando…
Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives
[Image: see text] In the present study, we report the photochemical transformation of pyrazolo[1,2-a]pyrazolone substrates that reach an excited state upon irradiation with visible light to initiate the homolytic C–N bond cleavage process that yields the corresponding N1-substituted pyrazoles. Moreo...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832495/ https://www.ncbi.nlm.nih.gov/pubmed/34077227 http://dx.doi.org/10.1021/acs.orglett.1c01376 |
_version_ | 1784648732519694336 |
---|---|
author | Petek, Nejc Brodnik, Helena Grošelj, Uroš Svete, Jurij Požgan, Franc Štefane, Bogdan |
author_facet | Petek, Nejc Brodnik, Helena Grošelj, Uroš Svete, Jurij Požgan, Franc Štefane, Bogdan |
author_sort | Petek, Nejc |
collection | PubMed |
description | [Image: see text] In the present study, we report the photochemical transformation of pyrazolo[1,2-a]pyrazolone substrates that reach an excited state upon irradiation with visible light to initiate the homolytic C–N bond cleavage process that yields the corresponding N1-substituted pyrazoles. Moreover, chemoselective heterolytic C–N bond cleavage is possible in the pyrazolo[1,2-a]pyrazole core in the presence of bromomalonate. |
format | Online Article Text |
id | pubmed-8832495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-88324952022-02-11 Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives Petek, Nejc Brodnik, Helena Grošelj, Uroš Svete, Jurij Požgan, Franc Štefane, Bogdan Org Lett [Image: see text] In the present study, we report the photochemical transformation of pyrazolo[1,2-a]pyrazolone substrates that reach an excited state upon irradiation with visible light to initiate the homolytic C–N bond cleavage process that yields the corresponding N1-substituted pyrazoles. Moreover, chemoselective heterolytic C–N bond cleavage is possible in the pyrazolo[1,2-a]pyrazole core in the presence of bromomalonate. American Chemical Society 2021-06-02 2021-07-16 /pmc/articles/PMC8832495/ /pubmed/34077227 http://dx.doi.org/10.1021/acs.orglett.1c01376 Text en © 2021 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Petek, Nejc Brodnik, Helena Grošelj, Uroš Svete, Jurij Požgan, Franc Štefane, Bogdan Visible-Light Driven Selective C–N Bond Scission in anti-Bimane-Like Derivatives |
title | Visible-Light Driven Selective C–N Bond Scission
in anti-Bimane-Like Derivatives |
title_full | Visible-Light Driven Selective C–N Bond Scission
in anti-Bimane-Like Derivatives |
title_fullStr | Visible-Light Driven Selective C–N Bond Scission
in anti-Bimane-Like Derivatives |
title_full_unstemmed | Visible-Light Driven Selective C–N Bond Scission
in anti-Bimane-Like Derivatives |
title_short | Visible-Light Driven Selective C–N Bond Scission
in anti-Bimane-Like Derivatives |
title_sort | visible-light driven selective c–n bond scission
in anti-bimane-like derivatives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832495/ https://www.ncbi.nlm.nih.gov/pubmed/34077227 http://dx.doi.org/10.1021/acs.orglett.1c01376 |
work_keys_str_mv | AT peteknejc visiblelightdrivenselectivecnbondscissioninantibimanelikederivatives AT brodnikhelena visiblelightdrivenselectivecnbondscissioninantibimanelikederivatives AT groseljuros visiblelightdrivenselectivecnbondscissioninantibimanelikederivatives AT svetejurij visiblelightdrivenselectivecnbondscissioninantibimanelikederivatives AT pozganfranc visiblelightdrivenselectivecnbondscissioninantibimanelikederivatives AT stefanebogdan visiblelightdrivenselectivecnbondscissioninantibimanelikederivatives |