The Role of Forkhead Box Family in Bone Metabolism and Diseases

Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease. Fox family genes are involved in cell differentiation, proliferation and apoptosis, embryonic development, aging, glucose and...

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Autores principales: Xu, Jianxiang, Wang, Kanbin, Zhang, Zengjie, Xue, Deting, Li, Weixu, Pan, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832510/
https://www.ncbi.nlm.nih.gov/pubmed/35153742
http://dx.doi.org/10.3389/fphar.2021.772237
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author Xu, Jianxiang
Wang, Kanbin
Zhang, Zengjie
Xue, Deting
Li, Weixu
Pan, Zhijun
author_facet Xu, Jianxiang
Wang, Kanbin
Zhang, Zengjie
Xue, Deting
Li, Weixu
Pan, Zhijun
author_sort Xu, Jianxiang
collection PubMed
description Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease. Fox family genes are involved in cell differentiation, proliferation and apoptosis, embryonic development, aging, glucose and lipid metabolism, and immune regulation. The regulatory role of the Fox family in the context of bone metabolism and orthopedic diseases is an emerging research hotspot. In this review, we highlight the major molecular mechanisms underlying the regulatory role of Fox factors in bone metabolism, bone development, bone homeostasis, and bone diseases associated with inhibition or upregulation of Fox factors. In addition, we discuss the emerging evidence in the realm of Fox factor-based therapeutics.
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spelling pubmed-88325102022-02-12 The Role of Forkhead Box Family in Bone Metabolism and Diseases Xu, Jianxiang Wang, Kanbin Zhang, Zengjie Xue, Deting Li, Weixu Pan, Zhijun Front Pharmacol Pharmacology Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease. Fox family genes are involved in cell differentiation, proliferation and apoptosis, embryonic development, aging, glucose and lipid metabolism, and immune regulation. The regulatory role of the Fox family in the context of bone metabolism and orthopedic diseases is an emerging research hotspot. In this review, we highlight the major molecular mechanisms underlying the regulatory role of Fox factors in bone metabolism, bone development, bone homeostasis, and bone diseases associated with inhibition or upregulation of Fox factors. In addition, we discuss the emerging evidence in the realm of Fox factor-based therapeutics. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8832510/ /pubmed/35153742 http://dx.doi.org/10.3389/fphar.2021.772237 Text en Copyright © 2022 Xu, Wang, Zhang, Xue, Li and Pan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xu, Jianxiang
Wang, Kanbin
Zhang, Zengjie
Xue, Deting
Li, Weixu
Pan, Zhijun
The Role of Forkhead Box Family in Bone Metabolism and Diseases
title The Role of Forkhead Box Family in Bone Metabolism and Diseases
title_full The Role of Forkhead Box Family in Bone Metabolism and Diseases
title_fullStr The Role of Forkhead Box Family in Bone Metabolism and Diseases
title_full_unstemmed The Role of Forkhead Box Family in Bone Metabolism and Diseases
title_short The Role of Forkhead Box Family in Bone Metabolism and Diseases
title_sort role of forkhead box family in bone metabolism and diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832510/
https://www.ncbi.nlm.nih.gov/pubmed/35153742
http://dx.doi.org/10.3389/fphar.2021.772237
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