Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

Coronavirus disease 2019 (COVID-19) represents a systemic disease that may cause severe metabolic complications in multiple tissues including liver, kidney, and cardiovascular system. However, the underlying mechanisms and optimal treatment remain elusive. Our study shows that impairment of ACE2 pat...

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Detalles Bibliográficos
Autores principales: Li, Zilun, Peng, Meixiu, Chen, Pin, Liu, Chenshu, Hu, Ao, Zhang, Yixin, Peng, Jiangyun, Liu, Jiang, Li, Yihui, Li, Wenxue, Zhu, Wei, Guan, Dongxian, Zhang, Yang, Chen, Hongyin, Li, Jiuzhou, Fan, Dongxiao, Huang, Kan, Lin, Fen, Zhang, Zefeng, Guo, Zeling, Luo, Hengli, He, Xi, Zhu, Yuanyuan, Li, Linghua, Huang, Bingding, Cai, Weikang, Gu, Lei, Lu, Yutong, Deng, Kai, Yan, Li, Chen, Sifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832557/
https://www.ncbi.nlm.nih.gov/pubmed/35150639
http://dx.doi.org/10.1016/j.cmet.2022.01.008

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