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Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report

Autoimmune limbic encephalitis is an antibody-mediated brain inflammatory process, which typically involves the medial temporal lobe. Diagnosis requires the presence of antineuronal antibodies, but sometimes patients present clinical features of limbic encephalitis despite negative serology. Thus, t...

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Autores principales: Lo Buono, Viviana, Bonanno, Lilla, Palmeri, Rosanna, Cammaroto, Simona, Morabito, Rosa, De Cola, Maria Cristina, Sessa, Edoardo, Marino, Silvia, Bramanti, Placido, Corallo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832620/
https://www.ncbi.nlm.nih.gov/pubmed/35137608
http://dx.doi.org/10.1177/03000605221078715
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author Lo Buono, Viviana
Bonanno, Lilla
Palmeri, Rosanna
Cammaroto, Simona
Morabito, Rosa
De Cola, Maria Cristina
Sessa, Edoardo
Marino, Silvia
Bramanti, Placido
Corallo, Francesco
author_facet Lo Buono, Viviana
Bonanno, Lilla
Palmeri, Rosanna
Cammaroto, Simona
Morabito, Rosa
De Cola, Maria Cristina
Sessa, Edoardo
Marino, Silvia
Bramanti, Placido
Corallo, Francesco
author_sort Lo Buono, Viviana
collection PubMed
description Autoimmune limbic encephalitis is an antibody-mediated brain inflammatory process, which typically involves the medial temporal lobe. Diagnosis requires the presence of antineuronal antibodies, but sometimes patients present clinical features of limbic encephalitis despite negative serology. Thus, the diagnosis of antibody-negative limbic encephalitis is difficult to make, and it must often rely largely on exclusion of other causes. This current case report describes a 28-year-old male that presented 2 months after the acute event with radiological changes typical of limbic encephalitis, but with no identifiable antibody and neuropsychological impairment. Antibody responses to neurotropic viruses and antibody-mediated encephalitis were negative in serum and cerebrospinal fluid. Magnetic resonance imaging showed signs of hyperintensity in the hippocampus bilaterally, amygdala and left pulvinar. The neuropsychological evaluation showed a deficit in emotional face recognition and severe autobiographical amnesia. Bilateral damage to the medial temporal lobe and hippocampus, including the amygdala, is associated with alterations in autobiographical memories. The neuropsychological impairment documented in this current case expands the range of clinical features of antibody-negative encephalitis and provides evidence that the memory deficit in this disorder is more extensive than was previously recognized.
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spelling pubmed-88326202022-02-12 Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report Lo Buono, Viviana Bonanno, Lilla Palmeri, Rosanna Cammaroto, Simona Morabito, Rosa De Cola, Maria Cristina Sessa, Edoardo Marino, Silvia Bramanti, Placido Corallo, Francesco J Int Med Res Case Reports Autoimmune limbic encephalitis is an antibody-mediated brain inflammatory process, which typically involves the medial temporal lobe. Diagnosis requires the presence of antineuronal antibodies, but sometimes patients present clinical features of limbic encephalitis despite negative serology. Thus, the diagnosis of antibody-negative limbic encephalitis is difficult to make, and it must often rely largely on exclusion of other causes. This current case report describes a 28-year-old male that presented 2 months after the acute event with radiological changes typical of limbic encephalitis, but with no identifiable antibody and neuropsychological impairment. Antibody responses to neurotropic viruses and antibody-mediated encephalitis were negative in serum and cerebrospinal fluid. Magnetic resonance imaging showed signs of hyperintensity in the hippocampus bilaterally, amygdala and left pulvinar. The neuropsychological evaluation showed a deficit in emotional face recognition and severe autobiographical amnesia. Bilateral damage to the medial temporal lobe and hippocampus, including the amygdala, is associated with alterations in autobiographical memories. The neuropsychological impairment documented in this current case expands the range of clinical features of antibody-negative encephalitis and provides evidence that the memory deficit in this disorder is more extensive than was previously recognized. SAGE Publications 2022-02-09 /pmc/articles/PMC8832620/ /pubmed/35137608 http://dx.doi.org/10.1177/03000605221078715 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Lo Buono, Viviana
Bonanno, Lilla
Palmeri, Rosanna
Cammaroto, Simona
Morabito, Rosa
De Cola, Maria Cristina
Sessa, Edoardo
Marino, Silvia
Bramanti, Placido
Corallo, Francesco
Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
title Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
title_full Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
title_fullStr Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
title_full_unstemmed Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
title_short Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
title_sort neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832620/
https://www.ncbi.nlm.nih.gov/pubmed/35137608
http://dx.doi.org/10.1177/03000605221078715
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