Cargando…
Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
Autoimmune limbic encephalitis is an antibody-mediated brain inflammatory process, which typically involves the medial temporal lobe. Diagnosis requires the presence of antineuronal antibodies, but sometimes patients present clinical features of limbic encephalitis despite negative serology. Thus, t...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832620/ https://www.ncbi.nlm.nih.gov/pubmed/35137608 http://dx.doi.org/10.1177/03000605221078715 |
_version_ | 1784648761923862528 |
---|---|
author | Lo Buono, Viviana Bonanno, Lilla Palmeri, Rosanna Cammaroto, Simona Morabito, Rosa De Cola, Maria Cristina Sessa, Edoardo Marino, Silvia Bramanti, Placido Corallo, Francesco |
author_facet | Lo Buono, Viviana Bonanno, Lilla Palmeri, Rosanna Cammaroto, Simona Morabito, Rosa De Cola, Maria Cristina Sessa, Edoardo Marino, Silvia Bramanti, Placido Corallo, Francesco |
author_sort | Lo Buono, Viviana |
collection | PubMed |
description | Autoimmune limbic encephalitis is an antibody-mediated brain inflammatory process, which typically involves the medial temporal lobe. Diagnosis requires the presence of antineuronal antibodies, but sometimes patients present clinical features of limbic encephalitis despite negative serology. Thus, the diagnosis of antibody-negative limbic encephalitis is difficult to make, and it must often rely largely on exclusion of other causes. This current case report describes a 28-year-old male that presented 2 months after the acute event with radiological changes typical of limbic encephalitis, but with no identifiable antibody and neuropsychological impairment. Antibody responses to neurotropic viruses and antibody-mediated encephalitis were negative in serum and cerebrospinal fluid. Magnetic resonance imaging showed signs of hyperintensity in the hippocampus bilaterally, amygdala and left pulvinar. The neuropsychological evaluation showed a deficit in emotional face recognition and severe autobiographical amnesia. Bilateral damage to the medial temporal lobe and hippocampus, including the amygdala, is associated with alterations in autobiographical memories. The neuropsychological impairment documented in this current case expands the range of clinical features of antibody-negative encephalitis and provides evidence that the memory deficit in this disorder is more extensive than was previously recognized. |
format | Online Article Text |
id | pubmed-8832620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-88326202022-02-12 Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report Lo Buono, Viviana Bonanno, Lilla Palmeri, Rosanna Cammaroto, Simona Morabito, Rosa De Cola, Maria Cristina Sessa, Edoardo Marino, Silvia Bramanti, Placido Corallo, Francesco J Int Med Res Case Reports Autoimmune limbic encephalitis is an antibody-mediated brain inflammatory process, which typically involves the medial temporal lobe. Diagnosis requires the presence of antineuronal antibodies, but sometimes patients present clinical features of limbic encephalitis despite negative serology. Thus, the diagnosis of antibody-negative limbic encephalitis is difficult to make, and it must often rely largely on exclusion of other causes. This current case report describes a 28-year-old male that presented 2 months after the acute event with radiological changes typical of limbic encephalitis, but with no identifiable antibody and neuropsychological impairment. Antibody responses to neurotropic viruses and antibody-mediated encephalitis were negative in serum and cerebrospinal fluid. Magnetic resonance imaging showed signs of hyperintensity in the hippocampus bilaterally, amygdala and left pulvinar. The neuropsychological evaluation showed a deficit in emotional face recognition and severe autobiographical amnesia. Bilateral damage to the medial temporal lobe and hippocampus, including the amygdala, is associated with alterations in autobiographical memories. The neuropsychological impairment documented in this current case expands the range of clinical features of antibody-negative encephalitis and provides evidence that the memory deficit in this disorder is more extensive than was previously recognized. SAGE Publications 2022-02-09 /pmc/articles/PMC8832620/ /pubmed/35137608 http://dx.doi.org/10.1177/03000605221078715 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Reports Lo Buono, Viviana Bonanno, Lilla Palmeri, Rosanna Cammaroto, Simona Morabito, Rosa De Cola, Maria Cristina Sessa, Edoardo Marino, Silvia Bramanti, Placido Corallo, Francesco Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report |
title | Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report |
title_full | Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report |
title_fullStr | Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report |
title_full_unstemmed | Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report |
title_short | Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report |
title_sort | neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832620/ https://www.ncbi.nlm.nih.gov/pubmed/35137608 http://dx.doi.org/10.1177/03000605221078715 |
work_keys_str_mv | AT lobuonoviviana neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT bonannolilla neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT palmerirosanna neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT cammarotosimona neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT morabitorosa neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT decolamariacristina neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT sessaedoardo neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT marinosilvia neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT bramantiplacido neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport AT corallofrancesco neuropsychologicalimplicationinpossibleantibodynegativelimbicencephalitisaclinicalcasereport |