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The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study

BACKGROUND: Peptic ulcer disease (PUD) is a common digestive disorder, of which the prevalence decreased in the past few decades. However, the decreasing tendency has plateaued in recent years due to changes in risk factors associated with the etiology of PUD, such as non-steroidal anti-inflammatory...

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Autores principales: Xie, Xin, Ren, Kaijie, Zhou, Zhangjian, Dang, Chengxue, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832644/
https://www.ncbi.nlm.nih.gov/pubmed/35144540
http://dx.doi.org/10.1186/s12876-022-02130-2
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author Xie, Xin
Ren, Kaijie
Zhou, Zhangjian
Dang, Chengxue
Zhang, Hao
author_facet Xie, Xin
Ren, Kaijie
Zhou, Zhangjian
Dang, Chengxue
Zhang, Hao
author_sort Xie, Xin
collection PubMed
description BACKGROUND: Peptic ulcer disease (PUD) is a common digestive disorder, of which the prevalence decreased in the past few decades. However, the decreasing tendency has plateaued in recent years due to changes in risk factors associated with the etiology of PUD, such as non-steroidal anti-inflammatory drug use. In this study, we investigated the epidemiological and the sociodemographic characteristics of PUD in 204 countries and territories from 1990 to 2019 based on data from the Global Burden of Disease, Injuries and Risk Factors (GBD) Study. METHODS: Demographic characteristics and annual prevalence, incidence, mortality, disability-adjusted life years (DALYs) and age-standardized death rate (ASR) data associated with PUD were obtained and analyzed. According to the sociodemographic index (SDI), the numbers of patients, ASRs, estimated annual percentage changes and geographical distributions were assessed with a generalized linear model and presented in world maps. All evaluations of numbers and rates were calculated per 100,000 population with 95% uncertainty intervals (UIs). RESULTS: In 2019, the global prevalence of PUD was approximately 8.09 [95% UI 6.79–9.58] million, representing a 25.82% increase from 1990. The age-standardized prevalence rate was 99.40 (83.86–117.55) per 100,000 population in 2019, representing a decrease of 143.37 (120.54–170.25) per 100,000 population from 1990. The age-standardized DALY rate in 2019 was decreased by 60.64% [74.40 (68.96–81.95) per 100,000 population] compared to that in 1990. In both sexes, the numbers and ASRs of the prevalence, incidence, deaths and DALYs were higher in males than in females over 29 years. Regionally, South Asia had the highest age-standardized prevalence rate [156.62 (130.58–187.05) per 100,000 population] in 2019. A low age-standardized death rate was found in the high-income super-region. Among nations, Kiribati had the highest age-standardized prevalence rate [330.32 (286.98–379.81) per 100,000 population]. Regarding socioeconomic status, positive associations between the age-standardized prevalence, incidence, death rate, DALYs and SDI were observed globally in 2019. CONCLUSIONS: Morbidity and mortality due to PUD decreased significantly from 1990 to 2019, while a gradual upward inclination has been observed in recent 15 years, which might be associated with changes in risk factors for PUD. Attention and efforts by healthcare administrators and society are needed for PUD prevention and control. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-022-02130-2.
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spelling pubmed-88326442022-02-11 The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study Xie, Xin Ren, Kaijie Zhou, Zhangjian Dang, Chengxue Zhang, Hao BMC Gastroenterol Research Article BACKGROUND: Peptic ulcer disease (PUD) is a common digestive disorder, of which the prevalence decreased in the past few decades. However, the decreasing tendency has plateaued in recent years due to changes in risk factors associated with the etiology of PUD, such as non-steroidal anti-inflammatory drug use. In this study, we investigated the epidemiological and the sociodemographic characteristics of PUD in 204 countries and territories from 1990 to 2019 based on data from the Global Burden of Disease, Injuries and Risk Factors (GBD) Study. METHODS: Demographic characteristics and annual prevalence, incidence, mortality, disability-adjusted life years (DALYs) and age-standardized death rate (ASR) data associated with PUD were obtained and analyzed. According to the sociodemographic index (SDI), the numbers of patients, ASRs, estimated annual percentage changes and geographical distributions were assessed with a generalized linear model and presented in world maps. All evaluations of numbers and rates were calculated per 100,000 population with 95% uncertainty intervals (UIs). RESULTS: In 2019, the global prevalence of PUD was approximately 8.09 [95% UI 6.79–9.58] million, representing a 25.82% increase from 1990. The age-standardized prevalence rate was 99.40 (83.86–117.55) per 100,000 population in 2019, representing a decrease of 143.37 (120.54–170.25) per 100,000 population from 1990. The age-standardized DALY rate in 2019 was decreased by 60.64% [74.40 (68.96–81.95) per 100,000 population] compared to that in 1990. In both sexes, the numbers and ASRs of the prevalence, incidence, deaths and DALYs were higher in males than in females over 29 years. Regionally, South Asia had the highest age-standardized prevalence rate [156.62 (130.58–187.05) per 100,000 population] in 2019. A low age-standardized death rate was found in the high-income super-region. Among nations, Kiribati had the highest age-standardized prevalence rate [330.32 (286.98–379.81) per 100,000 population]. Regarding socioeconomic status, positive associations between the age-standardized prevalence, incidence, death rate, DALYs and SDI were observed globally in 2019. CONCLUSIONS: Morbidity and mortality due to PUD decreased significantly from 1990 to 2019, while a gradual upward inclination has been observed in recent 15 years, which might be associated with changes in risk factors for PUD. Attention and efforts by healthcare administrators and society are needed for PUD prevention and control. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-022-02130-2. BioMed Central 2022-02-10 /pmc/articles/PMC8832644/ /pubmed/35144540 http://dx.doi.org/10.1186/s12876-022-02130-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Xie, Xin
Ren, Kaijie
Zhou, Zhangjian
Dang, Chengxue
Zhang, Hao
The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study
title The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study
title_full The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study
title_fullStr The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study
title_full_unstemmed The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study
title_short The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study
title_sort global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832644/
https://www.ncbi.nlm.nih.gov/pubmed/35144540
http://dx.doi.org/10.1186/s12876-022-02130-2
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