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Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos
The active site of the essential CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical αC-helix, is universally conserved in the single CDK1 ortholog of all metazoans. We report serial CDK1 duplications in the chordate, Oikopleura. Paralog diversificatio...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832800/ https://www.ncbi.nlm.nih.gov/pubmed/35155443 http://dx.doi.org/10.3389/fcell.2021.770939 |
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author | Ma, Xiaofei Øvrebø, Jan Inge Thompson, Eric M. |
author_facet | Ma, Xiaofei Øvrebø, Jan Inge Thompson, Eric M. |
author_sort | Ma, Xiaofei |
collection | PubMed |
description | The active site of the essential CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical αC-helix, is universally conserved in the single CDK1 ortholog of all metazoans. We report serial CDK1 duplications in the chordate, Oikopleura. Paralog diversifications in the PSTAIRE, activation loop substrate binding platform, ATP entrance site, hinge region, and main Cyclin binding interface, have undergone positive selection to subdivide ancestral CDK1 functions along the S-M phase cell cycle axis. Apparent coevolution of an exclusive CDK1d:Cyclin Ba/b pairing is required for oogenic meiosis and early embryogenesis, a period during which, unusually, CDK1d, rather than Cyclin Ba/b levels, oscillate, to drive very rapid cell cycles. Strikingly, the modified PSTAIRE of odCDK1d shows convergence over great evolutionary distance with plant CDKB, and in both cases, these variants exhibit increased specialization to M-phase. |
format | Online Article Text |
id | pubmed-8832800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88328002022-02-12 Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos Ma, Xiaofei Øvrebø, Jan Inge Thompson, Eric M. Front Cell Dev Biol Cell and Developmental Biology The active site of the essential CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical αC-helix, is universally conserved in the single CDK1 ortholog of all metazoans. We report serial CDK1 duplications in the chordate, Oikopleura. Paralog diversifications in the PSTAIRE, activation loop substrate binding platform, ATP entrance site, hinge region, and main Cyclin binding interface, have undergone positive selection to subdivide ancestral CDK1 functions along the S-M phase cell cycle axis. Apparent coevolution of an exclusive CDK1d:Cyclin Ba/b pairing is required for oogenic meiosis and early embryogenesis, a period during which, unusually, CDK1d, rather than Cyclin Ba/b levels, oscillate, to drive very rapid cell cycles. Strikingly, the modified PSTAIRE of odCDK1d shows convergence over great evolutionary distance with plant CDKB, and in both cases, these variants exhibit increased specialization to M-phase. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8832800/ /pubmed/35155443 http://dx.doi.org/10.3389/fcell.2021.770939 Text en Copyright © 2022 Ma, Øvrebø and Thompson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Ma, Xiaofei Øvrebø, Jan Inge Thompson, Eric M. Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos |
title | Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos |
title_full | Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos |
title_fullStr | Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos |
title_full_unstemmed | Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos |
title_short | Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos |
title_sort | evolution of cdk1 paralog specializations in a lineage with fast developing planktonic embryos |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832800/ https://www.ncbi.nlm.nih.gov/pubmed/35155443 http://dx.doi.org/10.3389/fcell.2021.770939 |
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