COVID-19-Associated Pulmonary Aspergillosis in a Series of Complete Autopsies from the Brazilian Amazon

Between April and July 2020, and, therefore, prior to the broad recommendation of corticosteroids for severe COVID-19, a total of 50 full autopsies were performed in Manaus. We confirmed two invasive cases of aspergillosis through histopathology and gene sequencing (4%) in our autopsy series. The co...

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Detalles Bibliográficos
Autores principales: Farias, Maria Eduarda, Santana, Monique Freire, Ferreira, Luiz, Borba, Mayla, Silva-Neto, João, Brito-Sousa, José Diego, Baía-da-Silva, Djane Clarys, João, Guilherme Pivoto, Val, Fernando, Simão, Mariana, Souza, João Vicente, Naveca, Felipe, Melo, Gisely, Monteiro, Wuelton, Lacerda, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832933/
https://www.ncbi.nlm.nih.gov/pubmed/34996046
http://dx.doi.org/10.4269/ajtmh.21-1009
Descripción
Sumario:Between April and July 2020, and, therefore, prior to the broad recommendation of corticosteroids for severe COVID-19, a total of 50 full autopsies were performed in Manaus. We confirmed two invasive cases of aspergillosis through histopathology and gene sequencing (4%) in our autopsy series. The confirmed invasive aspergillosis incidence seems much lower than expected based on the “probable and possible” definitions, and an individualized approach should be considered for each country scenario. Interestingly, a prolonged length of stay in the intensive care unit was not observed in any of the cases. Timely diagnosis and treatment of fungal infection can reduce mortality rates.

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