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Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali
Seasonal malaria chemoprevention (SMC) was adopted in Mali in 2012 for preventing malaria in children younger than 5 years. Although this strategy has been highly effective in reducing childhood malaria, an uptick in malaria occurrence has occurred in children 5 to 15 years of age. This study aimed...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832934/ https://www.ncbi.nlm.nih.gov/pubmed/34781256 http://dx.doi.org/10.4269/ajtmh.21-0046 |
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author | Konaté, Drissa Diawara, Sory Ibrahim Keita, Bourama Sogoba, Nafomon Fayiçal, Mahamadou Guindo, Agnès Thiam, Sibe Traoré, Sékou Fantamady Shaffer, Jeffrey G. Doumbia, Seydou Diakité, Mahamadou |
author_facet | Konaté, Drissa Diawara, Sory Ibrahim Keita, Bourama Sogoba, Nafomon Fayiçal, Mahamadou Guindo, Agnès Thiam, Sibe Traoré, Sékou Fantamady Shaffer, Jeffrey G. Doumbia, Seydou Diakité, Mahamadou |
author_sort | Konaté, Drissa |
collection | PubMed |
description | Seasonal malaria chemoprevention (SMC) was adopted in Mali in 2012 for preventing malaria in children younger than 5 years. Although this strategy has been highly effective in reducing childhood malaria, an uptick in malaria occurrence has occurred in children 5 to 15 years of age. This study aimed to investigate the feasibility of providing SMC to older children. A cohort of 350 children age 5 to 14 years were monitored during the 2019 transmission season in Dangassa, Mali. The intervention group received five monthly rounds of sulfadoxine–pyrimethamine plus amodiaquine, whereas the control group consisted of untreated children. Community acceptance for extending SMC was assessed during the final round. Logistic regression models were applied to compare the risk of Plasmodium falciparum malaria infection, anemia, and fever between the intervention and control groups. Kaplan-Meier survival analyses were used to compare the time to P. falciparum parasitemia infection between the groups. The community acceptance rate was 96.5% (139 of 144). Significant declines were observed in the prevalence of P. falciparum parasitemia (adjusted odds ratio, 0.22; 95% CI, 0.11–0.42) and anemia (adjusted odds ratio, 0.15; 95% CI, 0.07–0.28) in the intervention group compared with the control group. The cumulative incidence of P. falciparum infections was significantly greater (75.4%, 104 of 138) in the control group compared with the intervention group (40.7%, 61 of 143, P = 0.001). This study reveals that expanding SMC to older children is likely feasible, has high community acceptance, and is in reducing uncomplicated malaria and anemia in older children. |
format | Online Article Text |
id | pubmed-8832934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-88329342022-02-26 Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali Konaté, Drissa Diawara, Sory Ibrahim Keita, Bourama Sogoba, Nafomon Fayiçal, Mahamadou Guindo, Agnès Thiam, Sibe Traoré, Sékou Fantamady Shaffer, Jeffrey G. Doumbia, Seydou Diakité, Mahamadou Am J Trop Med Hyg Research Article Seasonal malaria chemoprevention (SMC) was adopted in Mali in 2012 for preventing malaria in children younger than 5 years. Although this strategy has been highly effective in reducing childhood malaria, an uptick in malaria occurrence has occurred in children 5 to 15 years of age. This study aimed to investigate the feasibility of providing SMC to older children. A cohort of 350 children age 5 to 14 years were monitored during the 2019 transmission season in Dangassa, Mali. The intervention group received five monthly rounds of sulfadoxine–pyrimethamine plus amodiaquine, whereas the control group consisted of untreated children. Community acceptance for extending SMC was assessed during the final round. Logistic regression models were applied to compare the risk of Plasmodium falciparum malaria infection, anemia, and fever between the intervention and control groups. Kaplan-Meier survival analyses were used to compare the time to P. falciparum parasitemia infection between the groups. The community acceptance rate was 96.5% (139 of 144). Significant declines were observed in the prevalence of P. falciparum parasitemia (adjusted odds ratio, 0.22; 95% CI, 0.11–0.42) and anemia (adjusted odds ratio, 0.15; 95% CI, 0.07–0.28) in the intervention group compared with the control group. The cumulative incidence of P. falciparum infections was significantly greater (75.4%, 104 of 138) in the control group compared with the intervention group (40.7%, 61 of 143, P = 0.001). This study reveals that expanding SMC to older children is likely feasible, has high community acceptance, and is in reducing uncomplicated malaria and anemia in older children. The American Society of Tropical Medicine and Hygiene 2022-02 2021-11-15 /pmc/articles/PMC8832934/ /pubmed/34781256 http://dx.doi.org/10.4269/ajtmh.21-0046 Text en © 2022 by The American Society of Tropical Medicine and Hygiene https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Konaté, Drissa Diawara, Sory Ibrahim Keita, Bourama Sogoba, Nafomon Fayiçal, Mahamadou Guindo, Agnès Thiam, Sibe Traoré, Sékou Fantamady Shaffer, Jeffrey G. Doumbia, Seydou Diakité, Mahamadou Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali |
title | Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali |
title_full | Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali |
title_fullStr | Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali |
title_full_unstemmed | Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali |
title_short | Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali |
title_sort | effectiveness and community acceptance of extending seasonal malaria chemoprevention to children 5 to 14 years of age in dangassa, mali |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832934/ https://www.ncbi.nlm.nih.gov/pubmed/34781256 http://dx.doi.org/10.4269/ajtmh.21-0046 |
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