Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate, and adaptive immunity. We have employed two orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins down-regulated by viral factors expres...

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Detalles Bibliográficos
Autores principales: Nightingale, Katie, Potts, Martin, Hunter, Leah M., Fielding, Ceri A., Zerbe, Cassie M., Fletcher-Etherington, Alice, Nobre, Luis, Wang, Eddie C. Y., Strang, Blair L., Houghton, Jack W., Antrobus, Robin, Suarez, Nicolas M., Nichols, Jenna, Davison, Andrew J., Stanton, Richard J., Weekes, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832970/
https://www.ncbi.nlm.nih.gov/pubmed/35105802
http://dx.doi.org/10.1073/pnas.2108173119

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