Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the “Bloom syndrome complex”) for dissolution of double Holliday junctions, key intermediates in homologous recombination. Mutations in any component of the Bloom syndrome complex can cause g...

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Detalles Bibliográficos
Autores principales: Hodson, Charlotte, Low, Jason K. K., van Twest, Sylvie, Jones, Samuel E., Swuec, Paolo, Murphy, Vincent, Tsukada, Kaima, Fawkes, Matthew, Bythell-Douglas, Rohan, Davies, Adelina, Holien, Jessica K., O’Rourke, Julienne J., Parker, Benjamin L., Glaser, Astrid, Parker, Michael W., Mackay, Joel P., Blackford, Andrew N., Costa, Alessandro, Deans, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832983/
https://www.ncbi.nlm.nih.gov/pubmed/35115399
http://dx.doi.org/10.1073/pnas.2109093119

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