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Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis
Sepsis, defined as a dysregulated host immune response to infection, is a common and dangerous clinical syndrome. The excessive host inflammatory response can induce immediate and persistent cognitive decline, which can be worse in older individuals. Sex-specific differences in the outcome of infect...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833110/ https://www.ncbi.nlm.nih.gov/pubmed/35094981 http://dx.doi.org/10.18632/aging.203868 |
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author | Rani, Asha Barter, Jolie Kumar, Ashok Stortz, Julie A. Hollen, McKenzie Nacionales, Dina Moldawer, Lyle L. Efron, Philip A. Foster, Thomas C. |
author_facet | Rani, Asha Barter, Jolie Kumar, Ashok Stortz, Julie A. Hollen, McKenzie Nacionales, Dina Moldawer, Lyle L. Efron, Philip A. Foster, Thomas C. |
author_sort | Rani, Asha |
collection | PubMed |
description | Sepsis, defined as a dysregulated host immune response to infection, is a common and dangerous clinical syndrome. The excessive host inflammatory response can induce immediate and persistent cognitive decline, which can be worse in older individuals. Sex-specific differences in the outcome of infectious diseases and sepsis appear to favor females. We employed a murine model to examine the influence of age and sex on the brain's microRNA (miR) response following sepsis. Young and old mice of both sexes underwent cecal ligation and puncture (CLP) with daily restraint stress. Expression of hippocampal miR was examined in age- and sex-matched controls at 1 and 4 days post-CLP. Few miR were modified in a similar manner across age or sex and these few miR were generally associated with neuroprotection against inflammation. Similar to previous work examining transcription, young females exhibited a better recovery of the miR profile from day 1 to day 4, relative to young males and old females. For young males and all female groups, the initial response mainly involved a decrease in miR expression. In contrast, old males exhibited only upregulated miR on day 1 and day 4 and many of the miR upregulated on day 1 and day 4 were linked to neurodegeneration, increased neuroinflammation, and cognitive impairment. The results emphasize age and sex differences in epigenetic mechanisms that likely contribute to susceptibility or resilience to cognitive impairment due to sepsis. |
format | Online Article Text |
id | pubmed-8833110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-88331102022-02-14 Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis Rani, Asha Barter, Jolie Kumar, Ashok Stortz, Julie A. Hollen, McKenzie Nacionales, Dina Moldawer, Lyle L. Efron, Philip A. Foster, Thomas C. Aging (Albany NY) Research Paper Sepsis, defined as a dysregulated host immune response to infection, is a common and dangerous clinical syndrome. The excessive host inflammatory response can induce immediate and persistent cognitive decline, which can be worse in older individuals. Sex-specific differences in the outcome of infectious diseases and sepsis appear to favor females. We employed a murine model to examine the influence of age and sex on the brain's microRNA (miR) response following sepsis. Young and old mice of both sexes underwent cecal ligation and puncture (CLP) with daily restraint stress. Expression of hippocampal miR was examined in age- and sex-matched controls at 1 and 4 days post-CLP. Few miR were modified in a similar manner across age or sex and these few miR were generally associated with neuroprotection against inflammation. Similar to previous work examining transcription, young females exhibited a better recovery of the miR profile from day 1 to day 4, relative to young males and old females. For young males and all female groups, the initial response mainly involved a decrease in miR expression. In contrast, old males exhibited only upregulated miR on day 1 and day 4 and many of the miR upregulated on day 1 and day 4 were linked to neurodegeneration, increased neuroinflammation, and cognitive impairment. The results emphasize age and sex differences in epigenetic mechanisms that likely contribute to susceptibility or resilience to cognitive impairment due to sepsis. Impact Journals 2022-01-30 /pmc/articles/PMC8833110/ /pubmed/35094981 http://dx.doi.org/10.18632/aging.203868 Text en Copyright: © 2022 Rani et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Rani, Asha Barter, Jolie Kumar, Ashok Stortz, Julie A. Hollen, McKenzie Nacionales, Dina Moldawer, Lyle L. Efron, Philip A. Foster, Thomas C. Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis |
title | Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis |
title_full | Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis |
title_fullStr | Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis |
title_full_unstemmed | Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis |
title_short | Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis |
title_sort | influence of age and sex on microrna response and recovery in the hippocampus following sepsis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833110/ https://www.ncbi.nlm.nih.gov/pubmed/35094981 http://dx.doi.org/10.18632/aging.203868 |
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