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The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice

Blood–brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key, mainly a deleterious role in the pathophysiology of ischemic stroke. Neddylation is a ubiquitylation-like pathway that is critical in various cellular functions by conjugating neuronal precursor cell-expressed deve...

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Detalles Bibliográficos
Autores principales:	Yu, Huilin, Luo, Haiyu, Chang, Luping, Wang, Shisheng, Geng, Xue, Kang, Lijing, Zhong, Yi, Cao, Yongliang, Wang, Ranran, Yang, Xing, Zhu, Yuanbo, Shi, Mei-Juan, Hu, Yue, Liu, Zhongwang, Yin, Xuhui, Ran, Yunwei, Yang, Hao, Fan, Wenying, Zhao, Bing-Qiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833173/ https://www.ncbi.nlm.nih.gov/pubmed/35101976 http://dx.doi.org/10.1073/pnas.2111896119

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